Alpha B Crystallin (CRYAB) (NM_001885) Human Recombinant Protein
$275.00
7 Weeks*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | E. coli |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-His |
| Predicted MW | 21.2 kDa |
| Concentration | lot specific |
| Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. |
| Endotoxin | < 0.1 EU per µg protein as determined by LAL test |
| Reconstitution Method | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. Dissolve the lyophilized protein in ddH2O. It is not recommended to reconstitute a concentration less than 100 µg/ml. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Stability | Stable for at least 6 months from date of receipt under proper storage and handling conditions. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NP_001876 |
| Locus ID | 1410 |
| UniProt ID | P02511 |
| Cytogenetics | 11q23.1 |
| Synonyms | CMD1II; CRYA2; CTPP2; CTRCT16; HEL-S-101; HSPB5; MFM2 |
| Summary | Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. provided by RefSeq, Jan 2019 |
| Protein Categories | Cardiovascular diseases, Intracellular Proteins, Membrane Proteins, Nervous system Diseases |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "Alpha B Crystallin" proteins (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH302718 | CRYAB MS Standard C13 and N15-labeled recombinant protein (NP_001876) | 10 ug |
$3,360.00
|
|
| LC419682 | Lyophilized CRYAB HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY419682 | Transient overexpression lysate of crystallin, alpha B (CRYAB) (as WB positive control) | 100 ug |
$436.00
|
|
| TP302718 | Recombinant protein of human crystallin, alpha B (CRYAB), 20 µg | 20 ug |
$737.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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