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Fgf1 (NM_010197) Mouse Recombinant Protein

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SKU
TP720034
Recombinant protein of mouse fibroblast growth factor acidic
Size:
10 ug 500 ug 50 ug 1 mg
  $190.00
7 Weeks*
Bulk/Customize

Other products for "Fgf1 or NM_010197"

Specifications
Specifications
Product Data
Species Mouse
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
Phe16-Asp155
Tag Tag Free
Predicted MW 15.8 kDa
Concentration lot specific
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a 0.2 um filtered solution of PBS,PH7.4.
Bioactivity ED50 is less than 0.5 ng/ml as determined by the dose-dependent stimulation of thymidine uptake by 3T3 cells in the presence of Heparin. Specific Activity of 2.0 x 106 IU/mg.
Endotoxin < 0.1 EU per µg protein as determined by LAL test
Reconstitution Method Always centrifuge tubes before opening. Do not mix by vortex or pipetting. Dissolve the lyophilized protein in ddH2O. It is not recommended to reconstitute a concentration less than 100 µg/ml. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Shipping Ambient
Reference Data
RefSeq NP_034327
Locus ID 14164
UniProt ID P61148
Cytogenetics 18 20.74 cM
RefSeq Size 3909
RefSeq ORF 465
Synonyms Dffrx; Fam; Fgf-1; Fgfa
Summary Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis.UniProtKB/Swiss-Prot Function
Protein Categories Growth Factors, Intracellular Proteins, Secreated Proteins
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Other "Fgf1" proteins (1)
SKU Description Size Price
TP501152 Purified recombinant protein of Mouse fibroblast growth factor 1 (Fgf1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug 20 ug
$1,020.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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