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RET (NM_020975) Human Recombinant Protein

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SKU
TP710180
Recombinant protein of human ret proto-oncogene (RET), transcript variant 2, residues 29-635aa, with C-terminal DDK tag, expressed in sf9, 20ug
Size:
20 ug
  $540.00
In Stock*
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Specifications
Specifications
Product Data
Species Human
Expression Host Sf9
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence from TrueORF clone, RC214268, encoding the region(Met-Leu29-Arg635) of Homo sapiens RET
Tag C-DDK
Predicted MW 67.78 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50 mM Tris-HCl, 100 mM glycine, pH 8.0, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_066124
Locus ID 5979
UniProt ID P07949
Cytogenetics 10q11.21
RefSeq Size 5629
RefSeq ORF 3342
Synonyms CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET-ELE1
Summary This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. provided by RefSeq, Sep 2017
Protein Categories ADC Targets, Cancer: Endocrine, Cancer: Lung, Enzyme: Kinases, Growth Factors, Intracellular Proteins, Membrane Proteins
Protein Families Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways Endocytosis, Pathways in cancer, Thyroid cancer
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Other "RET" proteins (6)
SKU Description Size Price
LC412167 Lyophilized RET HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC412424 Lyophilized RET HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY412167 Transient overexpression lysate of ret proto-oncogene (RET), transcript variant 2 (as WB positive control) 100 ug
$665.00
LY412424 Transient overexpression lysate of ret proto-oncogene (RET), transcript variant 4 (as WB positive control) 100 ug
$436.00
TP700176 Purified recombinant protein of human ret proto-oncogene (RET), with C-terminal DDK/His tag, expressed in human cells, 20 µg 20 ug
$900.00
TP710121 Recombinant protein of human ret proto-oncogene (RET), transcript variant 2, residues 708-1016aa, with C-terminal DDK tag,expressed in sf9 cells 20 ug
$540.00

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