OriGene Logo

Customer Login

Checkout as a new customer

Creating an account has many benefits:

  • See order and shipping status
  • Track order history
  • Check out faster
Create an Account

RXR-alpha / RXRA (111-228) Human Protein

Be the first to review this product
SKU
SA6040
Recombinant human RXR alpha/RXRA protein
Size:
100 ug
  $355.00
3 Weeks*
Bulk/Customize

Other products for "RXRA or NM_001291920"

Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
MLGLNGVLKV PAHPSGNMAS FTKHICAICG DRSSGKHYGV YSCEGCKGFF KRTVRKDLTY TCRDNKDCLI DKRQRNRCQY CRYQKCLAMG MKREAVQEER QRGKDRNENE VESTSSANE
Predicted MW 13.5 kDa (119aa) confirmed by MALDI-TOF
Concentration 1mg/ml (determined by Bradford assay)
Purity > 95% by SDS-PAGE
Presentation State Purified
Buffer Liquid in. 20mM Tris-HCl buffer (pH 7.5) containing 0.1M NaCl, 5mM beta-Mercaptoethanol
Preparation Liquid protein
Recommended Dilution SDS-PAGE
Protein Description The DNA binding domain of RXR (111-228 aa) was over expressed in E. coli and purified by using conventional column chromatography techniques.
Storage Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Reference Data
RefSeq NP_002948.1
Locus ID 6256
UniProt ID P19793
Cytogenetics 9q34.2
Synonyms RXRA, NR2B1, RXR-alpha, Retinoid X receptor, Retinoid X receptor alpha, Nuclear receptor subfamily 2 group B member 1, Retinoic acid receptor RXR-alpha, FLJ16020, FLJ16733, MGC102720, Retinoic acid receptor RXR alpha, RXR alpha1, RXRA1
Summary Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. provided by RefSeq, May 2014
Protein Categories Intracellular Proteins, Transciption Factors
Protein Families Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
Protein Pathways Adipocytokine signaling pathway, Non-small cell lung cancer, Pathways in cancer, PPAR signaling pathway, Small cell lung cancer, Thyroid cancer
Reviews
Write Review
 
 
 
 
 

Be the first to review this product

Please note:
Only reviews with images are eligible for a $20/20€ Amazon gift card.
Reviews without images are eligible for a $10/10€ Amazon gift card.
For more details about the terms and conditions, please visit the promotion page.

Review image
Documents
Resources

file-alt Citations

Modulation effects of black-vinegar based supplement against a high-fat dietary habit: antiobesity/hypolipidemic, antioxidative, and energy-metabolism effects
Liu, Chou, Li et al
J. Sci. Food Agric. (2020)
Cited by 10
AI Summary: In this study, OriGene’s RXRα antibody was used to assess protein expression changes in liver tissues, helping to elucidate the molecular mechanisms by which black-vinegar based supplements exert antiobesity and lipid-lowering effects in rats fed a high-fat diet.
Snippet: (1:3000 dilution, Santa Cruz Biotechnology Inc., Dallas, Texas, USA), PPARα (1:3000 dilution, Abcam PLC., Cambridge, UL), RXRα (1:3000 dilution, OriGene Technologies, Inc., Rockville, Maryland, USA), CPT1 (1:4000 dilution, Merck Millipore Co.), and UCP2
Curcumin inhibits the TGF-β1-dependent differentiation of lung fibroblasts via PPARγ-driven upregulation of cathepsins B and L
Saidi, Kasabova, Vanderlynden et al
Sci Rep (2019) 9 (1), 491 DOI: 10.1038/s41598-018-36858-3
Cited by 53
AI Summary: In this study, OriGene’s PPARγ siRNA (SR304257) was used to silence PPARγ expression, enabling the authors to demonstrate that curcumin’s inhibition of TGF-β1-dependent lung fibroblast differentiation is mediated through PPARγ-driven upregulation of cathepsins B and L.
FigureFigureFigure
A PPARγ-dependent miR-424/503-CD40 axis regulates inflammation mediated angiogenesis
Lee, Papangeli, Park et al
Sci Rep (2017) 7 (1), 2528 DOI: 10.1038/s41598-017-02852-4
AI Summary: OriGene products, specifically the PPARγ and RXRα constructs, were used to transfect HUVECs in order to investigate the regulation of miR-424/503 promoter activity in the study.
Snippet: HUVECs were transfected with miR-424/503 promoter-luciferase, renilla-luciferase, PPARγ and RXRα constructs (Origene)
Transient Maternal Hypothyroxinemia Potentiates the Transcriptional Response to Exogenous Thyroid Hormone in the Fetal Cerebral Cortex Before the Onset of Fetal Thyroid Function: A Messenger and MicroRNA Profiling Study
Dong, You, Williams et al
Cereb. Cortex (2014)
Cited by 31
AI Summary: OriGene products contributed to this study by providing the TRβ and RXRα expression plasmids, which were used to produce recombinant proteins for EMSA experiments investigating thyroid hormone receptor binding in the fetal cerebral cortex.
Snippet: EMSA was conducted using recombinant TRβ and RXRα produced in vitro by incubating the expression plasmids, TRβ and RXRα (OriGene Technologies, Rockville, MD, USA) with the TnT Quick Coupled Transcription/translation System (Promega, Madison, WI, USA ... Cite SaveSaving
A novel SNP in a vitamin D response element of the CYP24A1 promoter reduces protein binding, transactivation, and gene expression
Roff, Wilson
J Steroid Biochem Mol Biol (2008) 112 (1-3), 47-54 DOI: 10.1016/j.jsbmb.2008.08.009
Cited by 48
AI Summary: OriGene products, specifically the CYP24A1 cDNA clone (OriGene, SC119259) and CYP24A1 shRNA (OriGene, TL312259), were used in this study to analyze CYP24A1 gene function and expression, enabling the authors to assess the impact of the novel promoter SNP on protein binding, transactivation, and gene expression.
FigureFigure
Showing 1-5 of 5 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Related Products