HSPB1 / HSP27 (1-205) Human Protein
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | E. coli |
| Expression cDNA Clone or AA Sequence | |
| Predicted MW | 22.7 kDa (205aa) confirmed by MALDI-TOF |
| Concentration | 1mg/ml (determined by Bradford assay) |
| Purity | > 95% by SDS-PAGE |
| Presentation State | Purified |
| Buffer | Liquid in. 20mM HEPES buffer (pH 7.4) containing 100mM KCl, 1mM DTT |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
| Preparation | Liquid purified protein |
| Recommended Dilution | SDS-PAGE |
| Protein Description | Recombinant Human Hsp27 was overexpressed in E. coli and purified by conventional chromatography. |
| Storage | Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Reference Data | |
| RefSeq | NP_001531 |
| Locus ID | 3315 |
| UniProt ID | P04792 |
| Cytogenetics | 7q11.23 |
| Synonyms | Heat shock 27 kDa protein, Hspb1, Hsp25, Hsp27, Hsp27, HspB1, Heat shock 27 kDa protein, HSP 27, Growth-related 25 kDa protein, P25, HSP25, Heat shock protein beta-1, Heat shock 27 kDa protein 28 kDa heat shock protein, CMT2F, DKFZp586P1322, Estrogen regulated 24 kDa protein, at shock 25kDa protein 1, Heat shock 27kDa protein 1, Heat shock 28kDa protein 1, Heat Shock Protein 27, Heat shock protein beta 1, Heat Shock Protein27, HS.76067, Hsp 28, Hsp B1, Hsp28, HspB1, SRP27, Stress responsive protein 27. |
| Summary | This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. provided by RefSeq, Aug 2017 |
| Protein Categories | Growth Factors, Intracellular Proteins, Nervous system: Neurodegenerative diseases |
| Protein Pathways | MAPK signaling pathway, VEGF signaling pathway |
Reviews
Documents
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Resources
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Citations
Phosphorylation enhances recombinant HSP27 neuroprotection against focal cerebral ischemia in mice
Shimada, Tanaka, Shimura et al
Neuroscience (2014) 278, 113-21 DOI: 10.1016/j.neuroscience.2014.07.073
Shimada, Tanaka, Shimura et al
Neuroscience (2014) 278, 113-21 DOI: 10.1016/j.neuroscience.2014.07.073
Cited by 26
AI Summary: OriGene products contributed to this study by providing the recombinant HSP27 (rHSP27) protein, which was used to assess and compare the neuroprotective effects of phosphorylated and non-phosphorylated forms of HSP27 in a mouse model of cerebral ischemia.
Showing 1-1 of 1 papers.
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