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HSBP1 / HSF1BP (1-76) Human Protein

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SKU
SA6022
Recombinant human HSBP1 protein
Size:
100 ug
  $355.00
3 Weeks*
Bulk/Customize

Other products for "HSBP1 or NM_001537"

Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
MAETDPKTVQ DLTSVVQTLL QQMQDKFQTM SDQIIGRIDD MSSRIDDLEK NIADLMTQAG VEELESENKI PATQKS
Predicted MW 8.5 kDa (76aa) confirmed by MALDI-TOF
Concentration 1mg/ml (determined by BCA assay)
Purity > 95% by SDS-PAGE
Presentation State Purified
Buffer Liquid in. 20mM Tris-HCl buffer (pH 7.5) containing, 50mM NaCl, 20% glycerol
Preparation Liquid protein
Recommended Dilution SDS-PAGE
Protein Description This protein was overexpressed in E. coli and was purified to apparent homogeneity by using conventional column chromatography techniques.
Storage Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Reference Data
RefSeq NP_001528.1
Locus ID 3281
UniProt ID O75506
Cytogenetics 16q23.3
Synonyms Heat shock factor binding protein 1, NPC-A-13, HSF1BP, Nasopharyngeal carcinoma-associated antigen 13, NPC-A-13, Heat shock factor-binding protein 1, Heat shock factor binding protein 1, Nasopharyngeal carcinoma associated antigen 13, NPC A 13, NPCA 13
Summary The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. provided by RefSeq, Jul 2008
Protein Categories Intracellular Proteins
Protein Families Transcription Factors
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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