Alpha-Synuclein / SNCA (1-95) Human Protein

SKU SA6010X

Alpha-Synuclein / SNCA (1-95) human recombinant protein, 0.5 mg

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFV
• Predicted MW: 9.391 kDa
• Concentration: lot specific
• Purity: >95% by SDS-PAGE
• Presentation State: Purified
• Buffer: Presentation State: Purified; State: Liquid protein; Buffer System: 20 mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl
• Preparation: Liquid protein
• Protein Description: A deletion mutant of alpha-synuclein (amino acids 1-95), which contains the N-terminal amphipathic domain and NAC region.Alpha-synuclein 1-95 was overexpressed in E. coli and the recombinant protein was purified to apparent homogenity by using conventional column chromatography techniques.
• Storage: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice

Reference Data

• RefSeq: NP_000336
• Locus ID: 6622
• UniProt ID: P37840
• Cytogenetics: 4q22.1
• Synonyms: NACP, PARK1
• Summary: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
• Protein Families: Druggable Genome
• Protein Pathways: Alzheimer's disease, Parkinson's disease