Alpha-Synuclein / SNCA (96-140) Human Protein

CAT#: SA6007

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Alpha-Synuclein / SNCA (96-140) human protein, 0.1 mg


Product Datasheet for 'SA6007'


USD 260.00


Availability*
2 Weeks

Size
    • 100 ug


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Specifications

Product Data
Description Alpha-Synuclein / SNCA (96-140) human protein, 0.1 mg
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence MKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Predicted MW 5.217 kDa
Concentration 1.0 mg/ml
Purity >95% by SDS-PAGE
Buffer Presentation State: Purified
State: Liquid protein
Preparation Liquid protein
Protein Description A deletion mutant of α-synuclein (amino acids 96-140). Syn96-140 was overexpressed in E. coli and was purified to apparent homogeneity by taking advantage of the thermosolubility of protein and by using conventional column chromatography techniques. Additional amino acid(Met) is attatched at the N-terminus.
Storage Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Reference Data
RefSeq NP_000336
Locus ID 6622
Cytogenetics 4q22.1
Synonyms NACP; PARK1; PARK4; PD1
Summary Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Protein Families Druggable Genome
Protein Pathways Alzheimer's disease, Parkinson's disease

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