Alpha-Synuclein / SNCA (NACP112) Human Protein

CAT#: SA6005

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Alpha-Synuclein / SNCA (NACP112) human recombinant protein, 0.1 mg


Product Datasheet for 'SA6005'


USD 260.00


Availability*
2 Weeks

Size
    • 100 ug


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Specifications

Product Data
Description Alpha-Synuclein / SNCA (NACP112) human recombinant protein, 0.1 mg
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKEGYQDYEP EA
Predicted MW 11.3 kDa
Concentration 1.0 mg/ml (determined by BCA assay)
Purity >95% by SDS-PAGE
Buffer Presentation State: Purified
State: Liquid purified protein
Buffer System: 20 mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl.
Preparation Liquid purified protein
Protein Description An alternatively spliced (103-129) form of alpha-synuclein, alpha-Synuclein 112 was cloned into an E. coli expression vector by RT-PCR. The recombinant protein was purified to apparent homogeneity by taking advantage of the thermosolubility of the protein and by using conventional column chromatography techniques.
Storage Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Reference Data
RefSeq NP_000336
Locus ID 6622
Cytogenetics 4q22.1
Synonyms NACP; PARK1; PARK4; PD1
Summary Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Protein Families Druggable Genome
Protein Pathways Alzheimer's disease, Parkinson's disease

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