Alpha-Synuclein / SNCA (A30P/A53T Mutant) Human Protein

CAT#: SA6003X

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Alpha-Synuclein / SNCA (A30P/A53T Mutant) human protein, 0.5 mg


Product Datasheet for 'SA6003X'


USD 620.00


Availability*
2 Weeks

Size
    • 500 ug


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Specifications

Product Data
Description Alpha-Synuclein / SNCA (A30P/A53T Mutant) human protein, 0.5 mg
Species Human
Expression Host E. coli
Predicted MW 14.516 kDa
Purity >95%
Buffer Presentation State: Purified
Reference Data
RefSeq NP_000336
Locus ID 6622
Cytogenetics 4q22.1
Synonyms NACP; PARK1; PARK4; PD1
Summary Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Protein Families Druggable Genome
Protein Pathways Alzheimer's disease, Parkinson's disease

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