Alpha-Synuclein / SNCA (A30P/A53T Mutant) Human Protein

CAT#: SA6003

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Alpha-Synuclein / SNCA (A30P/A53T Mutant) human recombinant protein, 0.1 mg


Product Datasheet for 'SA6003'


USD 260.00


Availability*
2 Weeks

Size
    • 100 ug


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Specifications

Product Data
Description Alpha-Synuclein / SNCA (A30P/A53T Mutant) human recombinant protein, 0.1 mg
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence MDVFMKGLSK AKEGVVAAAE KTKQGVAEAP GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Predicted MW 14.516 kDa
Purity >95% by SDS-PAGE
Buffer Presentation State: Purified
State: Liquid protein
Buffer System: 20 mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl
Preparation Liquid protein
Protein Description A Parkinson's disease-related double mutant (A30P/A53T) of α-synuclein. The recombinant protein was purified to apparent homogeneity by taking advantage of the thermosolubility of the protein and by using conventional column chromatography techniques.
Note Real molecular weight on SDS-PAGE will be shift up (see picture below).
Storage Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Reference Data
RefSeq NP_000336
Locus ID 6622
Cytogenetics 4q22.1
Synonyms NACP; PARK1; PARK4; PD1
Summary Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Protein Families Druggable Genome
Protein Pathways Alzheimer's disease, Parkinson's disease

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