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Alpha-Synuclein / SNCA (1-140) Human Protein

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SKU
SA6001
Recombinant human alpha-Synuclein protein
Size:
100 ug
  $340.00
3 Weeks*
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Other products for "SNCA or NM_000345"

Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Predicted MW 14.4 kDa (140aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Concentration 1mg/ml (determined by BCA assay)
Purity > 95% by SDS-PAGE
Presentation State Purified
Buffer Liquid in. 20mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl, 1mM MgCl2
Endotoxin < 1 EU per 1ug of protein (determined by LAL method)
Preparation Liquid purified protein
Recommended Dilution SDS-PAGE
Protein Description Purified human recombinant alpha-Synuclein (amino acids 1-140).
Note Real molecular weight on SDS-PAGE will be shift up (see picture below).
Storage Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Reference Data
RefSeq NP_000336.1
Locus ID 6622
UniProt ID P37840
Cytogenetics 4q22.1
Synonyms SNCA, NACP, PARK1, PARK4, PD1, α-synuclein Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Parkinson disease 4, autosomal dominant Lewy body
Summary Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. provided by RefSeq, Feb 2016
Protein Categories Growth Factors, Intracellular Proteins, Nervous system: Neurodegenerative diseases
Protein Families Druggable Genome
Protein Pathways Alzheimer's disease, Parkinson's disease
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Documents
Resources

file-alt Citations

Disease Progression-Dependent Expression of CD200R1 and CX3CR1 in Mouse Models of Parkinson's Disease
Wang, Liu, Yan et al
Aging Dis (2020) 11 (2), 254-268 DOI: 10.14336/AD.2019.0615
AI Summary: In this study, OriGene products—specifically the CD200R1 antibody (Cat# TA326467) and CX3CR1 antibody (Cat# TA322465)—were used to detect and quantify the expression of CD200R1 and CX3CR1 proteins, enabling the researchers to assess how these immune checkpoints change during Parkinson’s disease progression in mouse models.
FigureFigureFigure
A stress-enhanced model for discovery of disease-modifying gene: Ece1-suppresses the toxicity of α-synuclein A30P
Chen, Tully
Neurobiol. Dis. (2018) 114, 153-163 DOI: 10.1016/j.nbd.2018.03.003
AI Summary: OriGene's human NACP140 cDNA (NM_000345.2) was used as the template to generate the A30P mutant α-synuclein construct for functional studies in this paper.
Snippet: Nuclear-localizing sequence (NLS) on RFP was generated by direct synthesis. A30P was created by creating a point mutation at the DNA codon of the 30th alanine, (G → C)CA, using human NACP140 (NM_000345.2;OriGene, MD, USA)
Showing 1-2 of 2 papers.
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