OriGene Logo

Customer Login

Checkout as a new customer

Creating an account has many benefits:

  • See order and shipping status
  • Track order history
  • Check out faster
Create an Account

CD340 / ERBB2 / HER2 Human Protein

Be the first to review this product
SKU
PA510X
CD340 / ERBB2 / HER2 human recombinant protein, 0.1 mg
Size:
100 ug
  $645.00
2 Weeks*
Bulk/Customize

Other products for "Her2 or NM_001005862"

Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
MTQVCTGTDM KLRLPASPET HLDMLRHLYQ GCQVVQGNLE LTYLPTNASL SFLQDIQEVQ GYVLIAHNQV RQVPLQRLRI VRGTQLFEDN YALAVLDNGD PLNNTTPVTG ASPGGLRELQ LRSLTEILKG GVLIQRNPQL CYQDTILWKD IFHKNNQLAL TLIDTNRSRA CHPCSPMCKG SRCWGESSED CQSLTRTVCA GGCARCKGPL PTDCCHEQCA AGCTGPKHSD CLACLHFNHS GICELHCPAL VTYNTDTFES MPNPEGRYTF GASCVTACPY NYLSTDVGSC TLVCPLHNQE VTAEDGTQRC EKCSKPCARG THSLPPRPAA VPVPLRMQPG PAHPVLSFLR PSWDLVSAFY SLPLAPLSPT SVPISPVSVG RGPDPDAHVA VDLSRYEG
Concentration lot specific
Purity >95%
Presentation State Purified
Buffer Presentation State: Purified
State: Lyophilized purified protein
Buffer System: 0.05 M Acetate buffer pH4
Reconstitution Method Restore with deionized water
Preparation Lyophilized purified protein
Recommended Dilution ELISA.
Western Blot.
Protein Description Total 398 AA. MW: 43.4 kDa (calculated). 397 AA of recombinant Human Herstatin and one extra AA, Nterminal methionin (highlighted).
Note Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Storage Store lyophilized (preferably in a desiccator) at -20°C and in aliquots at -80°C.
Reconstituted antibody can be stored at 4°C for a limited period of time; it does not show decline in activity after two weeks at 4°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Ambient
Reference Data
RefSeq NP_001005862
Locus ID 2064
UniProt ID P04626
Cytogenetics 17q12
Synonyms HER-2, NEU, p185erbB2, NGL, c-erbB-2, MNL19
Summary This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. provided by RefSeq, Jul 2008
Protein Categories ADC Targets, Cancer: Bladder, Cancer: Brain and CNS, Cancer: Gastrointestinal, Cancer: Gynecologic, Cancer: Head and Neck, CAR-T Targets, CD Markers, Enzyme: Kinases, Growth Factors, Intracellular Proteins, Membrane Proteins
Protein Families ELISA.
Western Blot.
Protein Pathways Adherens junction, Bladder cancer, Calcium signaling pathway, Endometrial cancer, ErbB signaling pathway, Focal adhesion, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer
Reviews
Write Review
 
 
 
 
 

Be the first to review this product

Please note:
Only reviews with images are eligible for a $20/20€ Amazon gift card.
Reviews without images are eligible for a $10/10€ Amazon gift card.
For more details about the terms and conditions, please visit the promotion page.

Review image
Documents
Resources

file-alt Citations

Modeling population size independent tissue epigenomes by ChIL-seq with single thin sections
Maehara, Tomimatsu, Harada et al
Mol Syst Biol (2021) 17 (11), e10323 DOI: 10.15252/msb.202110323
Cited by 6
AI Summary: OriGene products, specifically tissue samples from their catalog, were used as reference cancer samples to compare epigenomic profiles generated by the ChIL-seq method in this study.
Snippet: which was relatively lower than the other cancer samples (refer to catalog from Origene)
FigureFigureFigure
Highly Multiplexed Immunohistochemical MALDI-MS Imaging of Biomarkers in Tissues
Yagnik, Liu, Rothschild et al
J Am Soc Mass Spectrom (2021)
Cited by 156
AI Summary: OriGene contributed to this study by providing tissue specimens, which were essential for demonstrating the highly multiplexed immunohistochemical MALDI-MS imaging of biomarkers described in the paper.
Snippet: Immunohistochemistry (IHC) combined with fluorescence microscopy provides an important and widely used tool for researchers and pathologists to image multiple biomarkers in tissue specimens. Howeve...;The specimens were obtained from OriGene Technologies, Inc
Integrity of the Antiviral STING-mediated DNA Sensing in Tumor Cells Is Required to Sustain the Immunotherapeutic Efficacy of Herpes Simplex Oncolytic Virus
Froechlich, Caiazza, Gentile et al
Cancers (Basel) (2020) 12 (11) DOI: 10.3390/cancers12113407
Cited by 39
AI Summary: OriGene contributed to this study by providing the human HER2 transduction product (RC212583L1V), which was used to generate HER2-expressing CT26 tumor cells for experimental analysis of oncolytic virus efficacy.
Snippet: ern Blotting Substrate (Thermo Scientific, Waltham, MA, USA) was used for signal development, according to the manufacturer’s recommendations. Human HER2 transduction of CT26 cells was performed by Origene, Rockville, MD, USA, RC212583L1V. To evaluate the HER2 expression, cells were stained with FITC-conjugated anti-human HER2 (ab31891 Abcam, Cambridge, UK) and analyzed with FACS. 4.2. Cytotoxi
FigureFigureFigure
SOX10 - A Novel Marker for the Differential Diagnosis of Breast Metaplastic Squamous Cell Carcinoma
Qi, Hu, Xiao et al
Cancer Manag Res (2020) 12, 4039-4044 DOI: 10.2147/CMAR.S250867
AI Summary: In this study, the OriGene anti-rabbit polymer (PV-9000) was used as a secondary detection reagent in immunohistochemistry to help assess SOX10 expression in various squamous cell carcinoma samples, aiding the evaluation of SOX10 as a novel diagnostic marker for breast metaplastic squamous cell carcinoma.
Snippet: Sections were incubated overnight at 4°C with primary antibody and were subsequently incubated with anti-rabbit polymer (PV-9000, OriGene) for 30 min at room temperature. The slides were developed with DAB for 5 min, and followed by weakly hematoxylin
Figure
IHC
A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma
Kong, Mohamed Salleh, Ong et al
Nat Commun (2020) 11 (1), 1556 DOI: 10.1038/s41467-020-15318-5
Cited by 26
AI Summary: In this study, the turboGFP antibody from OriGene (cat. #TA150041) was used for immunoblotting and co-immunoprecipitation experiments to detect and analyze GFP-tagged proteins, facilitating the investigation of METN375S/HER2 interactions in squamous cell carcinoma models.
Snippet: or immunoblotting, p-MET (Tyr1234/1235, #3077), total MET (#8198), p-HER2 (Tyr1221/1222, #2243), total HER2 (#2165), p-p38 (Thr180/Tyr182, #4511), total p38 (#8690), p-Src (Tyr416, #2101), total Src (#2108), p-ERK1/2 (Thr202/Tyr204, #4377), total ERK1/2 (#4695), p-mTOR (Ser2448, #2971), total mTOR (#2172), p-Stat3 (Tyr705, #9131), total Stat3 (#4904), p-EGFR (Tyr1068, #2234), total EGFR (#2646), p-Akt (Ser473, #4060), total Akt (#9272), α-tubulin (#2125), horseradish peroxidase (HRP)-conjugated MET (#24294), HER2 (#60388), HSP90 (#4874), and β-actin (#5125) antibodies were purchased from Cell Signaling Technology;turboGFP antibody was from Origene (#TA150041);pan-Cadherin antibody (#ab22744) from Abcam. …
FigureFigureFigure
WB IP
Tuning the Antigen Density Requirement for CAR T Cell Activity
Majzner, Rietberg, Sotillo et al
Cancer Discov (2020)
AI Summary: OriGene’s full length Her2 lentiviral construct was used to transduce NALM6 cells, enabling the generation of cell clones with variable Her2 antigen densities for evaluating CAR T cell activity.
Snippet: …NALM6 cells were also transduced with a lentiviral construct encoding full length 517 Her2 (Origene) and then FACS sorted to different antigen densities. Cells went through one to 518 two rounds of single cell cloning to obtain clones expressing variable and distinct amounts of 519 Her2
Showing 1-6 of 21 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Related Products