Adiponectin (biologically active) Human Protein

CAT#: PA500X

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Adiponectin (biologically active) human protein, 0.1 mg



USD 600.00


Availability*
2 Weeks

Size
    • 100 ug


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Specifications

Product Data
Description Adiponectin (biologically active) human protein, 0.1 mg
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence ETTTQGPGVL LPLPKGACTG WMAGIPGHPG HNGAPGRDGR DGTPGEKGEK GDPGLIGPKG DIGETGVPGA EGPRGFPGIQ GRKGEPGEGA YVYRSAFSVG LETYVTIPNM PIRFTKIFYN QQNHYDGSTG KFHCNIPGLY YFAYHIVYMK DVKVSLFKKD KAMLFTYDQY QENNVDQASG SVLLHLEVGD QVWLQVYGEG ERNGLYADND NDSTFTGFLL YHDTNDYKDD DDK
Glu 1 to Gln 5 were confirmed by N-terminal sequencing.
Concentration 0.5 mg/mL
Purity >98% >98%
Buffer Presentation State: Purified
State: Lyophilized purified Protein
Buffer System: 20mM Tris buffer, 20 mM NaCl, pH 7.5
Bioactivity Biological: In vitro gluconeogenesis assay in primary hepatocytes was performed, showing the human adiponectin derived from mammalian cells can inhibit glucose production. The ED50 was ~6 µg/ml.
Reconstitution Restore with deionized water
Preparation Lyophilized purified Protein
Applications Cell culture and/or animal studies.
ELISA.
Western Blot.
Protein Description Human Adiponectin
Total 226 AA, UniProt Q15848 (Glu19 – Asn244)
Note Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Storage Store lyophilized (preferably in a desiccator) at -20°C and in aliquots at -80°C.
Reconstituted antibody can be stored at 4°C for a limited period of time; it does not show decline in activity after two weeks at 4°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Reference Data
RefSeq NP_001171271
Locus ID 9370
Cytogenetics 3q27.3
Synonyms ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1; GBP28
Summary This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Adipocytokine signaling pathway, PPAR signaling pathway, Type II diabetes mellitus

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