Interleukin-2 / IL2 Human Protein

CAT#: DA3559X

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Interleukin-2 / IL2 human protein, 50 µg



USD 270.00


Availability*
2 Weeks

Size
    • 50 ug


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Specifications

Product Data
Description Interleukin-2 / IL2 human protein, 50 µg
Species Human
Expression Host E. coli
Predicted MW 15.4 kDa
Concentration lot specific
Purity >97% > 98% by SDS-PAGE and Silver staining
Buffer Presentation State: Purified
State: Lyophilized protein, without buffer and stabilizer
Bioactivity Biological: The ED50 as determined by the dose-dependent stimulation of murine CTLL-2 cells is 0.1-0.5 ng/ml.
Specific: = 1 x 10e7 units/mg
Endotoxin < 0.1 ng per µg of IL-2
Reconstitution 100 mM acetic acid to a concentration of 100 ng/ml. This solution can be diluted into other buffered solutions or stored at -20°C for future use.
Preparation Lyophilized protein, without buffer and stabilizer
Storage Store lyophilized product at 2 - 8 °C for up to one month or at -20°C for longer. Following reconstitution store in aliquots at -20 °C. Avoid repeated freezing and thawing.
Stability Shelf life: One year from despatch.
Reference Data
RefSeq NP_000577
Locus ID 3558
UniProt ID P60568, Q0GK43
Cytogenetics 4q27
Synonyms IL-2; lymphokine; TCGF
Summary This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Sep 2020]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Allograft rejection, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Jak-STAT signaling pathway, T cell receptor signaling pathway, Type I diabetes mellitus

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