EGFR / ERBB1 Human Protein

CAT#: DA3557

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EGFR / ERBB1 human recombinant protein, 25 µg



USD 445.00


Availability*
2 Weeks

Size
    • 25 ug


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Specifications

Product Data
Description EGFR / ERBB1 human recombinant protein, 25 µg
Species Human
Expression Host Insect
Expression cDNA Clone or AA Sequence LEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSWSHPQFEK
Predicted MW ~ 80 kDa
Purity ~90% by SDS-PAGE and visualized by silver stain
Buffer Presentation State: Purified
State: Lyophilized protein
Buffer System: PBS, pH 7.4
Stabilizer: None
Bioactivity Biological: Measured by its ability to bind rhEGF in a functional ELISA (BioLISA)
Endotoxin < 0.1 ng per µg of sEGFR
Reconstitution The lyophilized sEGFR is soluble in water and most aqueous buffers and should be restored in water or PBS to a concentration of not lower than 0.1 mg/ml.
Preparation Lyophilized protein
Protein Description Recombinant Human soluble EGFR, fused to a C-terminal Strep-tag, is produced as a glycosylated monomeric protein with a mass of approximately 80kDa in insect cells.
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month 
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Reference Data
RefSeq NP_001333826
Locus ID 1956
Cytogenetics 7p11.2
Synonyms ERBB; ERBB1; HER1; mENA; NISBD2; PIG61
Summary The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]
Protein Families Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Secreted Protein, Stem cell relevant signaling - JAK/STAT signaling pathway, Transmembrane
Protein Pathways Adherens junction, Bladder cancer, Calcium signaling pathway, Colorectal cancer, Cytokine-cytokine receptor interaction, Dorso-ventral axis formation, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, GnRH signaling pathway, MAPK signaling pathway, Melanoma, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton

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