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PDGFB (PDGF-BB) Human Protein

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SKU
DA3553S
PDGFB (PDGF-BB) human recombinant protein, 2 µg
Size:
2 ug 5 ug
  $205.00
2 Weeks*
Bulk/Customize

Other products for "PDGFB or NM_002608"

Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Predicted MW 24.3 kDa
Purity >95% pure by SDS-PAGE and visualised by silver stain.
Presentation State Purified
Buffer Presentation State: Purified
State: Lyophilized purified protein
Buffer System: 50 mM Acetic Acid without stabilizer
Bioactivity Biological: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by Balb-c 3T3 cells is < 1 ng/ml.
Specific: > 1 x 10e6 units/mg
Endotoxin < 0.1 ng per ug of PDGF-BB
Preparation Lyophilized purified protein
Protein Description Recombinant Human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).
Storage Lyophilized Human PDGF-BB is stable for a few weeks at RT but best stored at -20°C. Reconsituted is best stored at -20°C to -70°C.
Avoid repeated freezing and thawing.
Stability Shelf life: One year from despatch.
Shipping Ambient
Reference Data
RefSeq NP_002599
Locus ID 5155
UniProt ID P01127
Cytogenetics 22q13.1
Synonyms Platelet-derived growth factor subunit B, PDGF beta, PDGF B, PDGF-B, Platelet-derived growth factor beta, PDGF subunit B, Platelet-derived growth factor B chain, PDGF2, PDGF-2, c-Sis, SIS, Becaplermin
Summary This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. provided by RefSeq, Oct 2015
Protein Categories Cancer: Brain and CNS, Cancer: Lung, Growth Factors, Intracellular Proteins, Nervous system: Neurodegenerative diseases, Secreated Proteins
Protein Families Druggable Genome
Protein Pathways Cytokine-cytokine receptor interaction, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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