PDGFA (PDGF-AB) Human Protein
PDGFA (PDGF-AB) human recombinant protein, 20 µg
|Description||PDGFA (PDGF-AB) human recombinant protein, 20 µg|
|Expression Host||E. coli|
|Predicted MW||25.5 kDa|
|Purity||>95% > 95%, by SDS-PAGE and visualised by silver stain.|
|Buffer||Presentation State: Purified
State: Lyophilized purified fraction.
|Bioactivity||Biological: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells is < 1 ng/ml.
Specific: > 1 x 10e6 units/mg.
|Endotoxin||< 0.1 ng per ug of PDGF-AB.|
|Preparation||Lyophilized purified fraction.|
|Protein Description||Recombinant human PDGF-AB is a 25.5 kDa disulfide-linked dimer, consisting of one A chain and one B chains (234 total amino acids).|
|Note||Always centrifuge product before opening vial!|
|Storage||Store The lyophilized PDGF-AB for one month at room temperature or -20°C. Reconstituted PDGF-AB should be stored in working aliquots at -20°C to -70°C.
Avoid repeated freeze-thaw cycles!
|Stability||Shelf life: One year from despatch.|
|Summary||This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]|
|Protein Families||Druggable Genome|
|Protein Pathways||Cytokine-cytokine receptor interaction, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.