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PDGFA (PDGF-AB) Human Protein

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SKU
DA3552X
PDGFA (PDGF-AB) human recombinant protein, 20 µg
Size:
20 ug
  $415.00
2 Weeks*
Bulk/Customize

Other products for "PDGFA or NM_002607"

Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Predicted MW 25.5 kDa
Purity > 95% by SDS-PAGE and visualised by silver stain.
Presentation State Purified
Buffer 50 mM Acetic Acid
Bioactivity Biological: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells is < 1 ng/ml.
Specific: > 1 x 10e6 units/mg.
Endotoxin < 0.1 ng per ug of PDGF-AB.
Reconstitution Method Centrifuge vial prior to opening. The lyophilized PDGF-AB should be reconstituted in 50mM acetic acid to a concentration not lower than 100μg/ml. For long term storage of reconstituted protein addition of carrier protein (e.g. BSA or HSA; 0.1%) is recommended.
Preparation Lyophilized purified fraction.
Protein Description Recombinant human PDGF-AB is a 25.5 kDa disulfide-linked dimer, consisting of one A chain and one B chains (234 total amino acids).
Note Always centrifuge product before opening vial!
Storage Store The lyophilized PDGF-AB for one month at room temperature or -20°C. Reconstituted PDGF-AB should be stored in working aliquots at -20°C to -70°C.
Avoid repeated freeze-thaw cycles!
Stability Shelf life: One year from despatch.
Shipping Ambient
Reference Data
RefSeq NP_002598
Locus ID 5154
UniProt ID P04085
Cytogenetics 7p22.3
Synonyms Platelet-derived growth factor subunit A, PDGF alpha, PDGF A, PDGF-A, Platelet-derived growth factor alpha, PDGF subunit A, Platelet-derived growth factor A chain, PDGF1, PDGF-1
Summary This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. provided by RefSeq, Oct 2015
Protein Categories Cancer: Brain and CNS, Cancer: Lung, Growth Factors, Intracellular Proteins, Secreated Proteins
Protein Families Druggable Genome
Protein Pathways Cytokine-cytokine receptor interaction, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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