PDGFA (PDGF-AB) Human Protein

CAT#: DA3552

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PDGFA (PDGF-AB) human recombinant protein, 5 µg



USD 190.00


Availability*
2 Weeks

Size
    • 5 ug


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Specifications

Product Data
Description PDGFA (PDGF-AB) human recombinant protein, 5 µg
Species Human
Expression Host E. coli
Predicted MW 25.5 kDa
Purity >95% > 95%, by SDS-PAGE and visualised by silver stain.
Buffer Presentation State: Purified
State: Lyophilized purified fraction.
Bioactivity Biological: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells is < 1 ng/ml.
Specific: > 1 x 10e6 units/mg.
Endotoxin < 0.1 ng per ug of PDGF-AB.
Preparation Lyophilized purified fraction.
Protein Description Recombinant human PDGF-AB is a 25.5 kDa disulfide-linked dimer, consisting of one A chain and one B chains (234 total amino acids).
Note Always centrifuge product before opening vial!
Storage Store The lyophilized PDGF-AB for one month at room temperature or -20°C. Reconstituted PDGF-AB should be stored in working aliquots at -20°C to -70°C.
Avoid repeated freeze-thaw cycles!
Stability Shelf life: One year from despatch.
Reference Data
RefSeq NP_002598
Locus ID 5154
Cytogenetics 7p22.3
Synonyms PDGF-A; PDGF1
Summary This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Protein Families Druggable Genome
Protein Pathways Cytokine-cytokine receptor interaction, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton

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