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GM-CSF Human Protein

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SKU
DA3544
GM-CSF human protein, 10 µg
Size:
10 ug 2 ug
  $300.00
2 Weeks*
Bulk/Customize

Other products for "CSF2 or NM_000758"

Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Predicted MW 14.5 kDa
Purity >98% > 98% by SDS-PAGE and HPLC analyses
Presentation State Purified
Buffer Presentation State: Purified
State: Lyophilized without stabilizer or preservative
Bioactivity Biological: Human GM-CSF is fully biologically active when compared to standard. The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is < / = 0.1 ng/ml.
For most in vitro applications, human GM-CSF exerts its biologival activity in the concentration range of 0.05 - 0.5 ng/ml.
Specific: 1x10e7 units/mg
Endotoxin < 0.1 ng per µg of GM-CSF
Reconstitution Method The lyophilized GM-CSF is soluble in water and most aqueous buffers.
The lyophilized powder can be reconstituted in water to a concentration of 0.1 mg/ml. This solution can be diluted into other buffered solutions or stored at -20°C for future use.
Preparation Lyophilized without stabilizer or preservative
Protein Description Human GM-CSF is a 14,6 kDa protein consisting of 123 amino acid residues
Storage The lyophilized protein is stable for one year from despatch at -20°C.
Reconstituted GM-CSF can be stored for three months in working aliquots at -20°C.
Avoid repeated freezing and thawing.
Shipping Ambient
Reference Data
RefSeq NP_000749
Locus ID 1437
UniProt ID P04141
Cytogenetics 5q31.1
Synonyms CSF2, GMCSF, Sargramostim, Molgramostin
Summary The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. This gene plays a role in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been detected in SARS-CoV-2 infected patients that develop acute respiratory distress syndrome. Mice deficient in this gene or its receptor develop pulmonary alveolar proteinosis. provided by RefSeq, Aug 2020
Protein Categories Cytokines, Growth Factors, Secreated Proteins
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein
Protein Pathways Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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