CD309 / VEGFR-2 / Flk-1 (D1-D7) Human Protein
$510.00
2 Weeks*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | Insect |
| Expression cDNA Clone or AA Sequence | |
| Predicted MW | 116 kDa |
| Purity | >95% pure as by SDS-PAGE and silver stain. |
| Presentation State | Purified |
| Buffer | Presentation State: Purified State: Lyophilized protein Buffer System: 25 mM MES, 150 mM NaCl, pH 5.5 Stabilizer: None |
| Bioactivity | Biological: Measured by its ability to inhibit the VEGF165-induced proliferation in Human Umbilical Vein Endothelial (HUVE) cells. Inhibition of VEGF165-induced proliferationof HUVECs byrecombinant sVEGFR-2/KDR (Cat.-No DA3530). |
| Endotoxin | < 0.1 ng per µg of sKDR |
| Reconstitution Method | The lyophilized Human sKDR is soluble in water and most aqueous buffers. Restore in water or PBS to a concentration of not lower than 0.1 mg/ml. |
| Preparation | Lyophilized protein |
| Protein Description | Recombinant Human soluble Endothelial Growth Factor Receptor-2 (sKDR D1-7) is produced as a non-chimeric protein in a monomeric form. The soluble receptor protein consists of all 7 extracellular domains, which contain all the information necessary for high affinity ligand binding. The receptor monomers have a mass of approximately 116kDa. Result by N-terminal sequencing: ASVGLPSVSL Length: 738 amino acids. |
| Storage | Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NP_002244 |
| Locus ID | 3791 |
| UniProt ID | P35968 |
| Cytogenetics | 4q12 |
| Synonyms | VEGFR2, FLK1, KDR, VEGF Receptor 2 |
| Summary | Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. provided by RefSeq, May 2009 |
| Protein Categories | ADC Targets, Cardiovascular diseases, CD Markers, Enzyme: Kinases, Growth Factors, Membrane Proteins |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane |
| Protein Pathways | Cytokine-cytokine receptor interaction, Endocytosis, Focal adhesion, VEGF signaling pathway |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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