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CD292 / BMPR1A Human Protein

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SKU
DA3521
CD292 / BMPR1A human recombinant protein, 0.1 mg
Size:
100 ug
  $485.00
2 Weeks*
Bulk/Customize

Other products for "BMPR1A or NM_004329"

Specifications
Specifications
Product Data
Species Human
Expression Host Insect
Predicted MW 23 kDa
Purity >90% pure by SDS-PAGE and silver staining
Presentation State Purified
Buffer Presentation State: Purified
State: Lyophilized purified protein
Buffer System: PBS
Stabilizer: None
Bioactivity Biological: Measured by its ability to inhibit recombinant human BMP-2 induced alkaline phosphatase production by C2C12 myogenic cells. The ED50 for this effect is typically 1-3 μg/ml in the presence of 500 ng/ml of recombinant human BMP-2.
Endotoxin < 0.1 ng per µg of BMPR-IA
Reconstitution Method The lyophilized sBMPR-1A is soluble in water and most aqueous buffers.
The lyophilized sBMPR-1A should be restored in PBS or medium to a concentration not lower than 50 μg/ml.
Preparation Lyophilized purified protein
Protein Description Recombinant soluble BMPR-IA binds BMP-2 and -4 with high-affinity in solution and is a potent BMP-2/4 antagonist in vitro. BMPR-IA is ubiquitously expressed during embryogenesis. In adult tissues, BMPR-IA mRNA is also widely distributed; with the highest expression levels found in skeletal muscle.
The extracellular domain of BMPR-IA shares little amino acid sequence identity with the other mammalian ALK type I receptor kinases, but the cysteine residues are conserved. Human and Mouse BMPR-IA are highly conserved and share 98% sequence identity.
Note Subunit: Monomeric glycoprotein
Storage Lyophilized samples are stable for six months at -20°C to -70°C.
Upon reconstitution, this cytokine can be stored under sterile conditions at 2-8°C for one month or at -20°C to -70°C for three months.
Avoid repeated freezing and thawing.
Shipping Ambient
Reference Data
RefSeq NP_004320
Locus ID 657
UniProt ID P36894
Cytogenetics 10q23.2
Synonyms ACVRLK3, ALK3, ALK-3, SKR5
Summary The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. provided by RefSeq, Jul 2008
Protein Categories CD Markers, Enzyme: Kinases, Growth Factors, Intracellular Proteins, Membrane Proteins
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, TGF-beta signaling pathway
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Documents
Resources

file-alt Citations

BMPR1A mutations in juvenile polyposis affect cellular localization
Howe, Dahdaleh, Carr et al
J. Surg. Res. (2013) 184 (2), 739-45 DOI: 10.1016/j.jss.2013.01.015
Cited by 26
AI Summary: OriGene’s pCMV6-AC-GFP BMPR1A expression vector was used to generate wild-type and mutant BMPR1A constructs, enabling the study of how JP-associated mutations alter BMPR1A cellular localization.
Snippet: green fluorescent protein (GFP) tagged wild-type BMPR1A expression vector in a pCMV6-AC-GFP construct (Origene, Rockville, MD ... competent bacterial cells, and selected colonies and extracted DNA using the PureLink Plasmid Quick Miniprep Kit (Life Technologies, Carlsbad
Showing 1-1 of 1 papers.
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