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FGF basic / FGF2 Human Protein

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SKU
DA3503
FGF basic / FGF2 human recombinant protein, 10 µg
Size:
10 ug
  $245.00
2 Weeks*
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Other products for "FGF2 or NM_002006"

Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
AGSITTLPAL PEDGGSGAFP PGHFKDPKRL YCKNGGFFLR IHPDGRVDGV REKSDPHIKL QLQAEERGVV SIKGVCANRY LAMKEDGRLL ASKCVTDECF FFERLESNNY NTYRSRKYTS WYVALKRGQY KLGSKTGPGQ KAILFLPMSA KS
Predicted MW 16.5 kDa
Purity >98% by SDS-PAGE and visualised by silver stain
Presentation State Purified
Buffer Presentation State: Purified
State: Lyophilized purified protein
Buffer System: PBS
Stabilizer: None
Bioactivity Biological: The ED50 for stimulation of cell proliferation in Human umbilical vein endothelial cells by Human FGF-2 (basic) has been determined to be in the range of 0.1-2 ng/ml.
Endotoxin < 0.1 ng per µg of FGF-basic
Reconstitution Method Restore in water containing at least 0.1% Human or Bovine Serum Albumin to a concentration not lower than 50 μg/ml.
Preparation Lyophilized purified protein
Protein Description Recombinant Human Fibroblast Growth Factor-2 (basic).
Result by N-terminal sequencing: AGSITTL
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month 
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Ambient
Reference Data
RefSeq NP_001997
Locus ID 2247
UniProt ID P09038
Cytogenetics 4q28.1
Synonyms FGFB, Heparin-binding growth factor 2, Fibroblast growth factor 2 (basic), BFGF, HBGF-2, HBGF2
Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. provided by RefSeq, Jul 2008
Protein Categories Chemokines, Cytokines, Growth Factors, Intracellular Proteins, Secreated Proteins
Protein Families Druggable Genome, Secreted Protein
Protein Pathways MAPK signaling pathway, Melanoma, Pathways in cancer, Regulation of actin cytoskeleton
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Documents
Resources

file-alt Citations

Interaction of Nerve Growth Factor β with Adiponectin and SPARC Oppositely Modulates its Biological Activity
Okura, Imao, Murashima et al
Int J Mol Sci (2019) 20 (7) DOI: 10.3390/ijms20071541
AI Summary: In this study, OriGene products—specifically the siRNAs targeting adiponectin receptors (AdipoR1 siRNA and AdipoR2 siRNA)—were used to silence adiponectin receptor expression in PC12 cells, enabling the authors to investigate the role of adiponectin-NGFβ interactions in modulating neurite outgrowth.
Snippet: Israel). Recombinant human basic FGF was purchased from Acris Antibodies GmbH (Hiddenhausen, Germany), while recombinant human VEGF-165 was purchased from Becton Dickison (Bedford, MA, USA). Recombinant
FigureFigureFigure
FGF2 gene activated matrices promote proliferation of bone marrow stromal cells
D'Mello, Elangovan, Salem
Arch Oral Biol (2015) 60 (12), 1742-9 DOI: 10.1016/j.archoralbio.2015.09.005
Cited by 22
AI Summary: OriGene’s human FGF2 plasmid (Cat# RC211125) was used in this study as the source of FGF2-encoding DNA for transfection, enabling the evaluation of gene-activated matrices in promoting bone marrow stromal cell proliferation.
FigureFigure
Using magnetic nanoparticles for gene transfer to neural stem cells: stem cell propagation method influences outcomes
Pickard, Adams, Barraud et al
J Funct Biomater (2015) 6 (2), 259-76 DOI: 10.3390/jfb6020259
Cited by 23
AI Summary: In this study, OriGene products—including the human FGF2-turboGFP plasmid, the control plasmid pCMV6-AN-GFP, and the anti-FGF2 antibody (clone 3D9)—were used to enable and verify gene transfer and expression in neural stem cells during the evaluation of magnetic nanoparticle-mediated transfection methods.
Snippet: the open reading frame of human FGF2 with a carboxy-terminal turboGFP tag (insert size 867 bp;total size 7.4 kb), control plasmid pCMV6-AN-GFP (herein termed pAN-GFP;size 6.6 kb) and anti-FGF2 antibody (clone 3D9) were all from OriGene Technologies (Rockville ... Cite SaveSaving
Showing 1-3 of 3 papers.
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