BMP2 / BMP2A Human Protein

CAT#: DA3502X

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BMP2 / BMP2A human recombinant protein, 25 µg

Product Datasheet for 'DA3502X'

USD 395.00

2 Weeks

    • 25 ug

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Product Data
Description BMP2 / BMP2A human recombinant protein, 25 µg
Species Human
Expression Host E. coli
Predicted MW 26 kDa
Purity >95% pure by SDS-PAGE and visualised by silver stain
Buffer Presentation State: Purified
State: Lyophilized purified Ig fraction
Buffer System: 50mM Acetic Acid
Stabilizer: None
Bioactivity Biological: Measured by the ability of BMP-2 to induce Alkaline Phosphatase production by C2C12 myogenic cells.
The ED50 for this effect is typically 0.3-0.8 µg/ml.
Specific: 2.5 x 103 units/mg
Endotoxin < 0.1 ng per µg of BMP-2
Reconstitution The lyophilized BMP-2 is best soluble in 50 mM Acetic Acid and at a concentration of 0.1 mg/ml but should be also soluble in most aqueous buffers when the pH is below 6.0
Preparation Lyophilized purified Ig fraction
Protein Description Human Bone Morphogenetic Protein-2 (BMP-2) is a disulfide-bonded homodimeric protein.
BMP-2 lacks the natural N-terminus which results in a 15-20 fold increase of specific activity. 
The amino acid sequence of recombinant Human BMP-2 starts with MQAKHKQ (position 283) containing the Met from the E. coli expression vector.
Storage Lyophilized samples are stable for 6 months from despatch at -20°C to -70°C.
Reconstituted BMP-2 should be stored in working aliquots at -20°C.
Avoid repeated freezing and thawing.
Reference Data
RefSeq NP_001191
Locus ID 650
Cytogenetics 20p12.3
Synonyms BDA2; BMP2A; SSFSC
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]
Protein Families Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Secreted Protein, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transmembrane
Protein Pathways Acute myeloid leukemia, Basal cell carcinoma, Cytokine-cytokine receptor interaction, Endocytosis, Hedgehog signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, TGF-beta signaling pathway


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