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BMP2 / BMP2A Human Protein

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SKU
DA3502X
BMP2 / BMP2A human recombinant protein, 25 µg
Size:
25 ug
  $655.00
2 Weeks*
Bulk/Customize

Other products for "BMP2 or NM_001200"

Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Predicted MW 26 kDa
Purity >95% pure by SDS-PAGE and visualised by silver stain
Presentation State Purified
Buffer Presentation State: Purified
State: Lyophilized purified Ig fraction
Buffer System: 50 mM Acetic Acid
Stabilizer: None
Bioactivity Biological: Measured by the ability of BMP-2 to induce Alkaline Phosphatase production by C2C12 myogenic cells.
The ED50 for this effect is typically 0.3-0.8 µg/ml.
Specific: 2.5 x 103 units/mg
Endotoxin < 0.1 ng per µg of BMP-2
Reconstitution Method The lyophilized BMP-2 is best soluble in 50 mM Acetic Acid and at a concentration of 0.1 mg/ml but should be also soluble in most aqueous buffers when the pH is below 6.0
Preparation Lyophilized purified Ig fraction
Protein Description Human Bone Morphogenetic Protein-2 (BMP-2) is a disulfide-bonded homodimeric protein.
BMP-2 lacks the natural N-terminus which results in a 15-20 fold increase of specific activity.
The amino acid sequence of recombinant Human BMP-2 starts with MQAKHKQ (position 283) containing the Met from the E. coli expression vector.
Storage Lyophilized samples are stable for 6 months from despatch at -20°C to -70°C.
Reconstituted BMP-2 should be stored in working aliquots at -20°C.
Avoid repeated freezing and thawing.
Shipping Ambient
Reference Data
RefSeq NP_001191
Locus ID 650
UniProt ID P12643
Cytogenetics 20p12.3
Synonyms Bone morphogenetic protein 2, BMP-2, BMP-2A
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. provided by RefSeq, Jul 2016
Protein Categories Cytokines, Growth Factors, Secreated Proteins
Protein Families Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Secreted Protein, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transmembrane
Protein Pathways Acute myeloid leukemia, Basal cell carcinoma, Cytokine-cytokine receptor interaction, Endocytosis, Hedgehog signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, TGF-beta signaling pathway
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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