Complement factor D (21-253, His-tag) Human Protein
Complement factor D (21-253, His-tag) human recombinant protein, 0.25 mg
|Description||Complement factor D (21-253, His-tag) human recombinant protein, 0.25 mg|
|Expression cDNA Clone or AA Sequence||PPRGRILGGR EAEAHARPYM ASVQLNGAHL CGGVLVAEQW VLSAAHCLED AADGKVQVLL GAHSLSQPEP SKRLYDVLRA VPHPDSQPDT IDHDLLLLQL SEKATLGPAV RPLPWQRVDR DVAPGTLCDV AGWGIVNHAG RRPDSLQHVL LPVLDRATCN RRTHHDGAIT ERLMCAESNR RDSCKGDSGG PLVCGGVLEG VVTSGSRVCG NRKKPGIYTR VASYAAWIDS VLAVEHHHHH H|
|Predicted MW||26.01 kDa|
|Purity||>95% by SDS - PAGE.|
|Buffer||Presentation State: Purified
State: Liquid purified protein
Buffer System: Phosphate buffered saline (pH7.4).
|Endotoxin||< 1.0 Eu per 1 microgram of protein (determined by LAL method)|
|Preparation||Liquid purified protein|
|Protein Description||Recombinant human CFD, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.|
|Storage||Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer.
Avoid repeated freezing and thawing.
|Stability||Shelf life: one year from despatch.|
|Synonyms||ADIPSIN; ADN; DF; PFD|
|Summary||This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015]|
|Protein Families||Druggable Genome, Protease, Secreted Protein|
|Protein Pathways||Complement and coagulation cascades|
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