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CADM1 / SYNCAM (45-374, His-Tag) Human Protein

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SKU
AR51660PU-N
Recombinant human IGSF4A/CADM1 protein
Size:
100 ug 20 ug
  $1,135.00
3 Weeks*
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Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
MGSSHHHHHH SSGLVPRGSH MGSQNLFTKD VTVIEGEVAT ISCQVNKSDD SVIQLLNPNR QTIYFRDFRP LKDSRFQLLN FSSSELKVSL TNVSISDEGR YFCQLYTDPP QESYTTITVL VPPRNLMIDI QKDTAVEGEE IEVNCTAMAS KPATTIRWFK GNTELKGKSE VEEWSDMYTV TSQLMLKVHK EDDGVPVICQ VEHPAVTGNL QTQRYLEVQY KPQVHIQMTY PLQGLTREGD ALELTCEAIG KPQPVMVTWV RVDDEMPQHA VLSGPNLFIN NLNKTDNGTY RCEASNIVGK AHSDYMLYVY DPPTTIPPPT TTTTTTTTTT TTILTIITDS RAGEEGSIRA VDH
Tag His-Tag
Predicted MW 39.4 kDa (353aa) confirmed by MALDI-TOF
Concentration 0.25mg/ml (determined by Bradford assay)
Purity > 85% by SDS-PAGE
Presentation State Purified
Buffer Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol, 1mM DTT
Preparation Liquid purified protein
Recommended Dilution SDS-PAGE
Protein Description Recombinant human CADM1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Storage Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Reference Data
RefSeq NP_055148
Locus ID 23705
UniProt ID Q9BY67
Cytogenetics 11q23.3
Synonyms Cell adhesion molecule 1, Immunoglobulin superfamily member 4, IgSF4, Nectin-like protein 2, NECL-2, Spermatogenic immunoglobulin superfamily, SgIgSF, Synaptic cell adhesion molecule, SynCAM, Tumor suppressor in lung cancer 1, TSLC-1, ST17, BL2, IGSF4A, SYNCAM1, RA175
Summary Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.UniProtKB/Swiss-Prot Function
Protein Categories Cancer: Head and Neck, Cytokines, Intracellular Proteins, Membrane Proteins
Protein Families Transmembrane
Protein Pathways Cell adhesion molecules (CAMs)
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Documents
Resources

file-alt Citations

CADM1 is essential for KSHV-encoded vGPCR-and vFLIP-mediated chronic NF-κB activation
Hunte, Alonso, Thomas et al
PLoS Pathog. (2018) 14 (4), e1006968 DOI: 10.1371/journal.ppat.1006968
AI Summary: OriGene Technologies contributed packaging plasmids used for the delivery of CADM1-specific shRNA and control scrambled shRNA constructs to knock down CADM1 expression in HEK 293T cells in this study.
Snippet: A CADM1-specific shRNA construct was used to knockdown CADM1 expression as described previously [44]. Briefly, HEK 293-T-cells in 6-well culture plates were transfected with 1 μg of control scrambled shRNA or CADM1 shRNA with 2 μg of packaging plasmids (OriGene Technologies) containing a puromycin selection marker using FuGENE 6 (Roche)
FigureFigureFigure
Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax Requires CADM1/TSLC1 for Inactivation of the NF-κB Inhibitor A20 and Constitutive NF-κB Signaling
Pujari, Hunte, Thomas et al
PLoS Pathog. (2015) 11 (3), e1004721 DOI: 10.1371/journal.ppat.1004721
Cited by 56
AI Summary: OriGene Technologies' packaging plasmids were used to produce lentiviral particles for shRNA-mediated knockdown of CADM1, enabling the authors to investigate CADM1's role in HTLV-1 Tax-mediated NF-κB activation.
Snippet: Lentiviral particle production and targeT-cell infection To investigate the role of CADM1 in Tax-mediated NF-κB activation, a CADM1-specific shRNA construct was used to knockdown CADM1 expression. HEK 293-T-cells in 6-well culture plates were transfected with 1 μg of control scrambled shRNA or CADM1 shRNA with 2 μg of packaging plasmids (OriGene Technologies) containing puromycin selection marker using FuGENE 6 (Roche). …
FigureFigureFigure
Showing 1-2 of 2 papers.
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