Properdin (28-469, His-Tag) Human Protein
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | E. coli |
| Expression cDNA Clone or AA Sequence | |
| Tag | His-Tag |
| Predicted MW | 50.9 kDa (465aa) |
| Concentration | 1mg/ml (determined by Bradford assay) |
| Purity | > 80% by SDS-PAGE |
| Presentation State | Purified |
| Buffer | Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol |
| Preparation | Liquid purified protein |
| Recommended Dilution | SDS-PAGE,Denatured |
| Protein Description | Recombinant human CFP protein, fused to His-tag at N-terminus, was expressed in E.coli. |
| Storage | Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Reference Data | |
| RefSeq | NP_002612 |
| Locus ID | 5199 |
| UniProt ID | P27918 |
| Cytogenetics | Xp11.23 |
| Synonyms | Complement factor properdin, BFD, PFC, PFD, PROPERDIN |
| Summary | This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.provided by RefSeq, Feb 2009 |
| Protein Categories | Immune system diseases, Intracellular Proteins, Secreated Proteins |
| Protein Families | Secreted Protein |
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