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Klotho Human Protein

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SKU
AR31175PU-N
Klotho human recombinant protein, 20 µg
Size:
20 ug
  $510.00
2 Weeks*
Bulk/Customize

Other products for "KL or NM_004795"

Specifications
Specifications
Product Data
Species Human
Expression Host CHO
Expression cDNA Clone or AA Sequence
Protein Sequence
EPGDGAQTWA RFSRPPAPEA AGLFQGTFPD GFLWAVGSAA YQTEGG WQQH GKGASIWDTF THHPLAPPGD SRNASLPLGA PSPLQPATGD V ASDSYNNVF RDTEALRELG VTHYRFSISW ARVLPNGSAG VPNREGL RYY RRLLERLREL GVQPVVTLYH WDLPQRLQDA YGGWANRALA DH FRDYAELC FRHFGGQVKY WITIDNPYVV AWHGYATGRL APGIRGSP RL GYLVAHNLLL AHAKVWHLYN TSFRPTQGGQ VSIALSSHWI NPR RMTDHSI KECQKSLDFV LGWFAKPVFI DGDYPESMKN NLSSILPDF T ESEKKFIKGT ADFFALCFGP TLSFQLLDPH MKFRQLESPN LRQL LSWIDL EFNHPQIFIV ENGWFVSGTT KRDDAKYMYY LKKFIMETLK AIKLDGVDVI GYTAWSLMDG FEWHRGYSIR RGLFYVDFLS QDKML LPKSS ALFYQKLIEK NGFPPLPENQ PLEGTFPCDF AWGVVDNYIQ VSQLTKPISS LTKPYH
Predicted MW 65-70 kDa
Purity >98% by SDS-PAGE and HPLC
Presentation State Purified
Buffer Presentation State: Purified
State: Lyophilized purified protein from 15 mM Sodium Phosphate (pH 7.3);
Stabilizer and preservatives: None
Bioactivity Biological: Determined by the dose-dependent stimulation of the proliferation of murine NIH-3T3 cells. Recombinant human Klotho is effective in a concentration range of 0.5-2.0 μg/ml.
Reconstitution Method Centrifuge the vial prior to opening. Do not vortex. 
The lyophilized Klotho should be reconstituted in water to a concentration of 0.1-1.0 mg/mL
Preparation Lyophilized purified protein
Protein Description Recombinant Human Klotho is a 65-70 kDa glycoprotein containing 516 amino acid residues.
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Ambient
Reference Data
RefSeq NP_004786
Locus ID 9365
UniProt ID Q9UEF7
Cytogenetics 13q13.1
Synonyms KL, Klotho, EC 3.2.1.31
Summary This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. provided by RefSeq, Jul 2008
Protein Categories Growth Factors, Membrane Proteins, Secreated Proteins
Protein Families Secreted Protein, Transmembrane
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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