CD54 / ICAM1 Human Protein
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | CHO |
| Expression cDNA Clone or AA Sequence | |
| Predicted MW | 72-80 kDa |
| Purity | >98% by SDS-PAGE and HPLC |
| Presentation State | Purified |
| Buffer | Presentation State: Purified State: Lyophilized purified protein Stabilizer: None |
| Bioactivity | Biological: ICAM-1 supported the adhesion of more than 50% PMA-stimulated HSB2 cells to plates coated at 25μg/ml ICAM-1 concentration |
| Endotoxin | < 0.1 ng per µg of ICAM-1 |
| Preparation | Lyophilized purified protein |
| Protein Description | Recombinant human ICAM-1 is a 49.5 kDa glycoprotein comprising the extracellular domain (453 amino acid residues) of ICAM-1. Monomeric glycosylated ICAM-1 migrates at an apparent molecular weight of approximately 72.0-80.0 kDa by SDS-PAGE analysis under reducing conditions. |
| Storage | Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NP_000192 |
| Locus ID | 3383 |
| UniProt ID | P05362 |
| Cytogenetics | 19p13.2 |
| Synonyms | ICAM-1 |
| Summary | This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. provided by RefSeq, Jul 2008 |
| Protein Categories | Allergies and autoimmune diseases, CD Markers, Intracellular Proteins, Membrane Proteins |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Natural killer cell mediated cytotoxicity, Viral myocarditis |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Citations
Dual action by fumaric acid esters synergistically reduces adhesion to human endothelium
Breuer, Herich, Schneider-Hohendorf et al
Mult Scler (2018) 24 (14), 1871-1882 DOI: 10.1177/1352458517735189
Breuer, Herich, Schneider-Hohendorf et al
Mult Scler (2018) 24 (14), 1871-1882 DOI: 10.1177/1352458517735189
Cited by 24
AI Summary: In this study, OriGene’s anti-HCA2/HCAR2 antibody (TA324872) was used to detect and analyze the expression of the hydroxycarboxylic acid receptor 2 (HCA2) on human brain-derived microvascular endothelial cells, helping to elucidate the mechanism by which fumaric acid esters reduce immune cell adhesion at the blood-brain barrier.
Superselective intraophthalmic artery chemotherapy in a nonhuman primate model: histopathologic findings
Tse, Steinle, Johnson et al
JAMA Ophthalmol (2013) 131 (7), 903-11 DOI: 10.1001/jamaophthalmol.2013.2065
Tse, Steinle, Johnson et al
JAMA Ophthalmol (2013) 131 (7), 903-11 DOI: 10.1001/jamaophthalmol.2013.2065
Cited by 43
AI Summary: In this study, OriGene products—including anti-ICAM-1 (TA506372) and anti-IL8 (TA324763) antibodies—were used to detect inflammatory markers in retinal endothelial cells, helping to demonstrate vascular toxicity after intraophthalmic artery chemotherapy in a nonhuman primate model.
Showing 1-2 of 2 papers.
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