BMP9 Human Protein
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | CHO |
| Expression cDNA Clone or AA Sequence | |
| Predicted MW | 24.1 kDa |
| Concentration | N/A |
| Purity | >95% by SDS-PAGE & HPLC analysis. Sequence: SAGAGSHCQK TSLRVNFEDI GWDSWIIAPK EYEAYECKGG CFFPLADDVT PTKHAIVQTL VHLKFPTKVG KACCVPTKLS PISVLYKDDM GVPTLKYHYE GMSVAECGCR |
| Presentation State | Purified |
| Buffer | Presentation State: Purified State: Lyophilized purified protein Stabilizer: None |
| Bioactivity | Biological: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.9 ng/ml. |
| Endotoxin | < 0.1 ng per μg of GDF-2 |
| Reconstitution Method | We recommended a quick spin followed by reconstitution in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted into other aqueous buffers and stored at 4°C for one week or at –20°C for future use. |
| Preparation | Lyophilized purified protein |
| Protein Description | Recombinant human GDF-2 is a 24.1 kDa disulfide linked homodimeric protein consisting of two 110 amino acid polypeptide chains. |
| Note | Centrifuge vials before opening! |
| Storage | Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NP_057288 |
| Locus ID | 2658 |
| UniProt ID | Q9UK05 |
| Cytogenetics | 10q11.22 |
| Synonyms | GDF-2, GDF2 |
| Summary | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development, angiogenesis and differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia. provided by RefSeq, Jul 2016 |
| Protein Categories | Cytokines, Growth Factors, Secreated Proteins |
| Protein Families | Druggable Genome, Secreted Protein |
Reviews
Documents
| FAQs |
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Resources
| Recombinant Protein Resources |
Citations
A bioactive collagen membrane that enhances bone regeneration
Khorsand, Elangovan, Hong et al
J. Biomed. Mater. Res. Part B Appl. Biomater. (2018)
Khorsand, Elangovan, Hong et al
J. Biomed. Mater. Res. Part B Appl. Biomater. (2018)
AI Summary: OriGene Technologies supplied the plasmid DNA encoding human BMP-9, which was incorporated into collagen membranes to enhance bone regeneration in this study.
Snippet: (St. Louis, MO). Plasmid DNA encoding human BMP-9 (ORF size 1290 bp) possessing a cytomegalovirus promoter/ enhancer was provided by Origene Technologies, Inc. (Rockville, MD). PolyA-120 containing T7 pVAX1 was pro- vided by Life Technologies (Madison
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