CD62E / E-Selectin Human Protein
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | CHO |
| Expression cDNA Clone or AA Sequence | |
| Predicted MW | 65-85 |
| Purity | >95% by SDS-PAGE & HPLC analysis |
| Presentation State | Purified |
| Buffer | Presentation State: Purified State: Lyophilized purified protein Stabilizer: None |
| Bioactivity | Biological: Measured by its ability to support adhesion of U937 cells, a human hystiocytic lymphoma cell line. |
| Reconstitution Method | Restore in water to a concentration of 0.1-1.0 mg/ml. |
| Preparation | Lyophilized purified protein |
| Protein Description | Recombinant human E-selectin is a 58.6 kDa protein containing 535 amino acid residues, corresponding to the extracellular portion of the full length protein. Due to glycosylation, E-selectin migrates at an apparent molecular weight of approximately 65-85 kDa by SDS-PAGE analysis under reducing conditions. |
| Note | Centrifuge vials before opening! |
| Storage | Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NP_000441 |
| Locus ID | 6401 |
| UniProt ID | P16581 |
| Cytogenetics | 1q24.2 |
| Synonyms | SELE, ELAM1, LECAM2 |
| Summary | The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. provided by RefSeq, Jul 2008 |
| Protein Categories | CD Markers, Cytokines, Intracellular Proteins, Membrane Proteins |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Cell adhesion molecules (CAMs) |
Reviews
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Resources
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Citations
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