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CD22 Human Protein

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SKU
AR31157PU-N
CD22 human recombinant protein, 20 µg
Size:
20 ug
  $510.00
2 Weeks*
Bulk/Customize

Other products for "FLJ22814 or NM_024916"

Specifications
Specifications
Product Data
Species Human
Expression Host CHO
Expression cDNA Clone or AA Sequence
Protein Sequence
SKWVFEHPET LYAWEGACVW IPCTYRALDG DLESFILFHN PEYNKN TSKF DGTRLYESTK DGKVPSEQKR VQFLGDKNKN CTLSIHPVHL N DSGQLGLRM ESKTEKWMER IHLNVSERPF PPHIQLPPEI QESQEVT LTC LLNFSCYGYP IQLQWLLEGV PMRQAAVTST SLTIKSVFTR SE LKFSPQWS HHGKIVTCQL QDADGKFLSN DTVQLNVKHT PKLEIKVT PS DAIVREGDSV TMTCEVSSSN PEYTTVSWLK DGTSLKKQNT FTL NLREVTK DQSGKYCCQV SNDVGPGRSE EVFLQVQYAP EPSTVQILH S PAVEGSQVEF LCMSLANPLP TNYTWYHNGK EMQGRTEEKV HIPK ILPWHA GTYSCVAENI LGTGQRGPGA ELDVQYPPKK VTTVIQNPMP IREGDTVTLS CNYNSSNPSV TRYEWKPHGA WEEPSLGVLK IQNVG WDNTT IACARCNSWC SWASPVALNV QYAPRDVRVR KIKPLSEIHS GNSVSLQCDF SSSHPKEVQF FWEKNGRLLG KESQLNFDSI SPEDAG SYSC WVNNSIGQTA SKAWTLEVLY APRRLRVSMS PGDQVMEGKS A TLTCESDAN PPVSHYTWFD WNNQSLPHHS QKLRLEPVKV QHSGAYW CQG TNSVGKGRSP LSTLTVYYSP ETIGRR
Predicted MW 75 kDa
Purity >98% by SDS-PAGE & HPLC analysis
Presentation State Purified
Buffer Presentation State: Purified
State: Lyophilized purified protein
Buffer System: PBS without stabilizers
Bioactivity Biological: Determined by its ability to inhibit the proliferation of Raji cells. The expected ED50 for this effect is 10-17 μg/ml.
Reconstitution Method We recommended a quick spin followed by reconstitution in water to a concentration of 0.1-1.0 mg/ml.
This solution can be diluted into other aqueous buffers and stored at 4°C for one week or at –20°C for future use.
Preparation Lyophilized purified protein
Protein Description Recombinant Human CD22 is a soluble 75.0 kDa (666 amino acid residues) protein which corresponds to the extracellular domain of CD22.
Note Centrifuge vials before opening!
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Ambient
Reference Data
Locus ID 79978
Cytogenetics 19q13.13
Synonyms SIGLEC2, Siglec-2, B-cell receptor CD22, Leu-14, BL-CAM
Summary CD22 is a 135 kDa B-cell restricted sialoglycoprotein that binds to oligosaccharides containing 2-6-linked sialic acid residues. It is present in the cytoplasm of nearly all B-lineage cells and is also expressed on the surface of B-cells during advance stages of differentiation. Although the exact physiological function of CD22 is unclear, it appears to play a role in B-cell activation and to act as an adhesion molecule. The potential therapeutic use of CD22 and anti-CD22 may be useful in diagnostic and/or treatment of leukemia, lymphoma, non-Hodgkin's lymphoma and certain autoimmune conditions. (Cesano A. and Gayko U. Semin. Oncol. Apr. 2003 (2): 253-257).
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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