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BMP7 Human Protein

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SKU
AR31155PU-N
BMP7 human recombinant protein, 10 µg
Size:
10 ug
  $510.00
2 Weeks*
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Other products for "BMP7 or NM_001719"

Specifications
Specifications
Product Data
Species Human
Expression Host CHO
Expression cDNA Clone or AA Sequence
Protein Sequence
MANVAENSSS DQRQACKKHE LYVSFRDLGW QDWIIAPEGY AAYYCE GECA FPLNSYMNAT NHAIVQTLVH FINPETVPKP CCAPTQLNAI S VLYFDDSSN VILKKYRNMV VRACGCH
Predicted MW 28.8 kDa
Purity >98% by SDS-PAGE & HPLC analysis
Presentation State Purified
Buffer Presentation State: Purified
State: Lyophilized purified protein
Buffer System: PBS without stabilizers
Bioactivity Biological: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.02-0.04 μg/ml.
Endotoxin < 0.1 ng per µg of BMP-7
Reconstitution Method Restore in PBS to a concentration not lower than 50 µg/ml.
The lyophilized sTIE-2/hFc is soluble in water and most aqueous buffers.
Preparation Lyophilized purified protein
Protein Description Recombinant Human BMP-7 is a 28.8 kDa homodimeric glycoprotein consisting of two 116 amino acid subunits, which correspond to amino acid residues 316 to 431 of the full-length BMP-7 precursor.
Note Centrifuge vials before opening!
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Ambient
Reference Data
RefSeq NP_001710
Locus ID 655
UniProt ID P18075
Cytogenetics 20q13.31
Synonyms BMP-7, Bone morphogenetic protein 7, OP1, Osteogenic protein 1
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. provided by RefSeq, Jul 2016
Protein Categories Cytokines, Growth Factors, Intracellular Proteins, Secreated Proteins
Protein Families Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Secreted Protein, Stem cell relevant signaling - TGFb/BMP signaling pathway
Protein Pathways Cytokine-cytokine receptor interaction, Hedgehog signaling pathway, TGF-beta signaling pathway
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Documents
Resources

file-alt Citations

Up-regulation of Bone Morphogenetic Protein 7 by 2-Hydroxycinnamaldehyde Attenuates HNSCC Cell Invasion
Kang, Kim, Kang et al
Anticancer Res. (2018) 38 (10), 5747-5757 DOI: 10.21873/anticanres.12913
AI Summary: OriGene’s pCMV-BMP7 overexpression vector was used in this study to increase BMP7 expression in HNSCC cells, enabling the researchers to demonstrate that BMP7 upregulation attenuates cell invasion and mediates the anti-migratory effects of 2’-hydroxycinnamaldehyde.
Snippet: After 8 h, the medium containing the transfection mixture was replaced with fresh serum-containing medium. Exogenous BMP7 overexpression vector (pCMV-BMP7) was obtained from Origene Technologies (Rockville, MD, USA). Statistical analysis
Showing 1-1 of 1 papers.
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