BMP7 Human Protein
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Other products for "BMP7"
Specifications
Product Data | |
Species | Human |
Expression Host | CHO |
Expression cDNA Clone or AA Sequence |
MANVAENSSS DQRQACKKHE LYVSFRDLGW QDWIIAPEGY AAYYCE GECA FPLNSYMNAT NHAIVQTLVH FINPETVPKP CCAPTQLNAI S VLYFDDSSN VILKKYRNMV VRACGCH
|
Predicted MW | 28.8 kDa |
Purity | >98% by SDS-PAGE & HPLC analysis |
Presentation | Purified |
Buffer | Presentation State: Purified State: Lyophilized purified protein Buffer System: PBS without stabilizers |
Bioactivity | Biological: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.02-0.04 μg/ml. |
Endotoxin | < 0.1 ng per µg of BMP-7 |
Reconstitution | Restore in PBS to a concentration not lower than 50 µg/ml. The lyophilized sTIE-2/hFc is soluble in water and most aqueous buffers. |
Preparation | Lyophilized purified protein |
Protein Description | Recombinant Human BMP-7 is a 28.8 kDa homodimeric glycoprotein consisting of two 116 amino acid subunits, which correspond to amino acid residues 316 to 431 of the full-length BMP-7 precursor. |
Note | Centrifuge vials before opening! |
Storage | Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_001710 |
Locus ID | 655 |
UniProt ID | P18075, A8K571 |
Cytogenetics | 20q13.31 |
Synonyms | OP-1 |
Summary | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016] |
Protein Families | Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Secreted Protein, Stem cell relevant signaling - TGFb/BMP signaling pathway |
Protein Pathways | Cytokine-cytokine receptor interaction, Hedgehog signaling pathway, TGF-beta signaling pathway |
Documents
FAQs |
SDS |
Resources
Recombinant Protein Resources |
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