OriGene Logo

Customer Login

Checkout as a new customer

Creating an account has many benefits:

  • See order and shipping status
  • Track order history
  • Check out faster
Create an Account

SERPINE1 / PAI1 (Wild type) Mouse Protein

Be the first to review this product
SKU
AR31009PU-N
SERPINE1 / PAI1 (Wild type) mouse recombinant protein, 0.5 mg
Size:
500 ug
  $3,425.00
2 Weeks*
Bulk/Customize

Other products for "SERPINE1 or NM_000602"

Specifications
Specifications
Product Data
Species Mouse
Expression Host E. coli
Predicted MW 43 kDa
Concentration lot specific
Purity >98% by SDS-PAGE.
80 +/- 5% active by uPA titration. Purified by Column chromatography
Presentation State Purified
Buffer Presentation State: Purified
State: Liquid purified protein
Buffer System: 0.05M Sodium Acetate, 0.1M Sodium Chloride, 1 mM EDTA, pH 5.0 without preservatives
Preparation Liquid purified protein
Protein Description Recombinant Human Plasminogen Activator Inhibitor 1 (PAI-1), wild type. Does not contain a fusion partner.
Storage Store (in aliquots) at -70°C
Aliquot to avoid multiple freeze/thaw cycles.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Reference Data
RefSeq NP_000593
Locus ID 5054
UniProt ID P05121
Cytogenetics 7q22.1
Synonyms Serpin E1, PLANH1, Plasminogen Activator Inhibitor 1, PAI-1, PAI
Summary This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. The protein also functions as a component of innate antiviral immunity. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. provided by RefSeq, Aug 2020
Protein Categories Cardiovascular diseases, Secreated Proteins
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Complement and coagulation cascades, p53 signaling pathway
Reviews
Write Review
 
 
 
 
 

Be the first to review this product

Please note:
Only reviews with images are eligible for a $20/20€ Amazon gift card.
Reviews without images are eligible for a $10/10€ Amazon gift card.
For more details about the terms and conditions, please visit the promotion page.

Review image
Documents
Resources

file-alt Citations

Silencing of Ago-2 Interacting Protein SERBP1 Relieves KCC2 Repression by miR-92 in Neurons
Barbato, Frisone, Braccini et al
Cells (2022) 11 (6) DOI: 10.3390/cells11061052
Cited by 10
AI Summary: OriGene’s full-length Serpine1 3′UTR clone (SC119781) was used to generate reporter constructs for studying the role of SERBP1 in miRNA-mediated regulation in this paper.
Snippet: EcoRI/NotI). PSSG: control firefly luciferase no containing 3′UTR was derived from SG-Luc-SLC12A5. Serpine1 3′UTR: The last 1332 nts of the Serpine1 3′UTR within the full-length clone SC119781 (Origene, Rockville, MD, USA) (SacII/NotI) and the first 509 nts of the Serpine1 3′UTR within the SG-Luc- Serpine1 plasmid (XbaI/SacII) (Amplicon start: chr7: 100362990;Amplicon end: chr7: 100363963
FigureFigureFigure
Alteration in global DNA methylation status following preconditioning injury influences axon growth competence of the sensory neurons
Shin, Kim, Kwon et al
Exp. Neurol. (2020) 326, 113177 DOI: 10.1016/j.expneurol.2020.113177
Cited by 28
AI Summary: OriGene contributed SOCS3 and Serpine1 expression vectors, which were used to overexpress these genes in dorsal root ganglia neurons to assess their roles as negative regulators of axon regeneration in the study.
Snippet: secondary antibody. Intraganglionic injection of adeno-associated viruses (AAVs) SOCS3 and Serpine1 expression vectors were purchased from OriGene and subcloned into the pBL-AAV vector (kindly provided by Dr. Sang Ryong Kim, Kyungpook National University
Mineralocorticoid Receptor (MR) Trans-Activation of Inflammatory AP-1 Signaling: Dependence on DNA Sequence, MR Conformation, and AP-1 Family Member Expression
Dougherty, Elinoff, Ferreyra et al
J. Biol. Chem. (2016)
AI Summary: OriGene products, specifically the DDK-myc/pCMV6 empty vector, human GR-DDK-myc/pCMV6, and MR-DDK-myc/pCMV6 plasmids, were used to transiently transfect HEK293 cells for overexpression studies of glucocorticoid and mineralocorticoid receptors, enabling investigation of their roles in inflammatory AP-1 signaling.
Snippet: Forty-eight hours prior to transfection, 5x105 HEK293 cells were seeded onto 35 mm plates. Cells were transiently transfected with 1 µg of empty-vector (DDK-myc/pCMV6;Origene, Rockville, MD) plus 0.5 µg of human GRDDK-myc/pCMV6 (Origene), MR-DDKmyc/pCMV6 (Origene), or additional empty-vector using lipofectamine 2000 (Life Technologies)
Redox regulation of soluble epoxide hydrolase by 15-deoxy-delta-prostaglandin J2 controls coronary hypoxic vasodilation
Charles, Burgoyne, Mayr et al
Circ. Res. (2011) 108 (3), 324-34 DOI: 10.1161/CIRCRESAHA.110.235879
Cited by 16
AI Summary: OriGene contributed to this study by providing the cDNA for mouse wild-type soluble epoxide hydrolase (sEH), which was used to generate both wild-type and mutant (Cys521Ser) sEH constructs for investigating the redox regulation of sEH in coronary vasodilation.
Snippet: 15. sEH Wild-Type and Cys521Ser Construct Generation. The cDNA for mouse wild-type sEH was obtained from Origene and the Cys521Ser mutant created using the QuikChanger kit (Stratagene). Assessing Whether Thiol-Oxidizing Agents Inhibit sEH in Cells.
Showing 1-4 of 4 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Related Products