TDO2 / TDO (1-406, His-Tag) Human Protein
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | E. coli |
| Expression cDNA Clone or AA Sequence | |
| Tag | His-Tag |
| Predicted MW | 50 kDa (426aa) confirmed by MALDI-TOF |
| Concentration | 0.25mg/ml (determined by Bradford assay) |
| Purity | > 90% by SDS-PAGE |
| Presentation State | Purified |
| Buffer | Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 5mM DTT, 1mM EDTA, 30% glycerol |
| Preparation | Liquid purified protein |
| Recommended Dilution | SDS-PAGE |
| Protein Description | Recombinant human TDO2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
| Storage | Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Reference Data | |
| RefSeq | NP_005642 |
| Locus ID | 6999 |
| UniProt ID | P48775 |
| Cytogenetics | 4q32.1 |
| Synonyms | Tryptophan 23-dioxygenase, Tryptophan 2,3-dioxygenase, TDO, TPH2, TRPO |
| Summary | This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. provided by RefSeq, Feb 2012 |
| Protein Categories | Intracellular Proteins |
| Protein Pathways | Metabolic pathways, Tryptophan metabolism |
Reviews
Documents
| FAQs |
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Resources
| Recombinant Protein Resources |
Citations
Deep learning model enables the discovery of a novel immunotherapeutic agent regulating the kynurenine pathway
Kim, Lee, Lee et al
Oncoimmunology (2021) 10 (1), 2005280 DOI: 10.1080/2162402X.2021.2005280
Kim, Lee, Lee et al
Oncoimmunology (2021) 10 (1), 2005280 DOI: 10.1080/2162402X.2021.2005280
AI Summary: OriGene products, specifically the human IDO1 cDNA clone (Cat# RC209744) and TDO2 cDNA clone (Cat# RC209849), were used in this study to express and analyze the enzymatic activity of IDO1 and TDO2, enabling the evaluation of the novel inhibitor STB-C017’s effects on these key enzymes in the kynurenine pathway.
EWS-FLI1 impairs aryl hydrocarbon receptor activation by blocking tryptophan breakdown via the kynurenine pathway
Mutz, Schwentner, Kauer et al
FEBS Lett (2016) 590 (14), 2063-75 DOI: 10.1002/1873-3468.12243
Mutz, Schwentner, Kauer et al
FEBS Lett (2016) 590 (14), 2063-75 DOI: 10.1002/1873-3468.12243
Cited by 12
AI Summary: In this study, OriGene’s EWS-FLI1 shRNA (OriGene, TL320082) was used to knock down EWS-FLI1 expression in Ewing sarcoma cells, enabling the authors to investigate how EWS-FLI1 regulates tryptophan metabolism and aryl hydrocarbon receptor activation.
Showing 1-2 of 2 papers.
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