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Galectin-3 (1-250, His-Tag) Human Protein

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SKU
AR09297PU-L
Recombinant human Galectin-3/LGALS3 protein
Size:
500 ug
  $1,000.00
3 Weeks*
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Other products for "LGALS3 or NM_001357678"

Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
MADNFSLHDA LSGSGNPNPQ GWPGAWGNQP AGAGGYPGAS YPGAYPGQAP PGAYPGQAPP GAYPGAPGAY PGAPAPGVYP GPPSGPGAYP SSGQPSATGA YPATGPYGAP AGPLIVPYNL PLPGGVVPRM LITILGTVKP NANRIALDFQ RGNDVAFHFN PRFNENNRRV IVCNTKLDNN WGREERQSVF PFESGKPFKI QVLVEPDHFK VAVNDAHLLQ YNHRVKKLNE ISKLGISGDI DLTSASYTMI
Tag His-Tag
Predicted MW 28.3 kDa (270aa) confirmed by MALDI-TOF
Concentration 0.5mg/ml (determined by Bradford assay)
Purity > 95% by SDS-PAGE
Presentation State Purified
Buffer Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT, 0.1M NaCl
Bioactivity The ED50 for this effect is less or equal to 15ug/ml. Measured by its ability to agglutinate human red blood cells.
Preparation Liquid purified protein
Recommended Dilution SDS-PAGE, Bioactivity
Protein Description Recombinant Galectin-3 protein, fused to His-tag, was expressed in E.coli and purified by using conventional chromatography techniques.
Storage Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Reference Data
RefSeq NP_002297.2
Locus ID 3958
UniProt ID P17931
Cytogenetics 14q22.3
Synonyms Gal-3, 35 kDa lectin, Carbohydrate-binding protein 35, CBP 35, Galactose-specific lectin 3, Galactoside-binding protein, GALBP, IgE-binding protein, L-31, Laminin-binding protein, Lectin L-29, Mac-2 antigen, MAC2, Advanced glycation end-product receptor 3, GALIG
Summary This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.provided by RefSeq, Oct 2014
Protein Categories Intracellular Proteins, Secreated Proteins
Protein Families Secreted Protein
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Documents
Resources

file-alt Citations

Self-assembled glycopeptide nanofibers as modulators of galectin-1 bioactivity
Restuccia, Tian, Collier et al
Cell Mol Bioeng (2015) 8 (3), 471-487 DOI: 10.1007/s12195-015-0399-2
Cited by 58
AI Summary: In this paper, OriGene products—specifically the Human Galectin-1 protein (Cat# TP720435) and Human Galectin-3 protein (Cat# TP721256)—were used to assess the binding affinity and bioactivity modulation of self-assembled glycopeptide nanofibers toward galectin-1 and galectin-3.
FigureFigure
Showing 1-1 of 1 papers.
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