TARC / CCL17 (24-94, His-Tag) Human Protein
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | E. coli |
| Expression cDNA Clone or AA Sequence | |
| Tag | His-Tag |
| Predicted MW | 10.3 kDa (92aa) confirmed by MALDI-TOF |
| Concentration | 0.5mg/ml (determined by Bradford assay) |
| Purity | > 95% by SDS-PAGE |
| Presentation State | Purified |
| Buffer | Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
| Preparation | Liquid purified peptide |
| Recommended Dilution | SDS-PAGE |
| Protein Description | CCL17, fused to His-tag, was expressed in E.coli and purifed by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer. |
| Storage | Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Reference Data | |
| RefSeq | NP_002978 |
| Locus ID | 6361 |
| UniProt ID | Q92583 |
| Cytogenetics | 16q21 |
| Synonyms | Chemokine (C-C motif) ligand 17, A-152E5.3, ABCD-2, SCYA17, TARC, Chemokine (C-C motif) ligand 17 A152E53, ABCD2, CC Chemokine TARC, CCL17, Chemokine CC Motif Ligand 17, MGC138271, MGC138273, Small Inducible Cytokine A17, Small Inducible Cytokine A17 Precursor, Small Inducible Cytokine Subfamily A (Cys Cys), Small Inducible Cytokine Subfamily A (Cys Cys) Member 17, T Cell Directed CC Chemokine, Thymus and activation regulated chemokine |
| Summary | This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. provided by RefSeq, Sep 2014 |
| Protein Categories | Chemokines, Cytokines, Secreated Proteins |
| Protein Families | Druggable Genome, Secreted Protein |
| Protein Pathways | Chemokine signaling pathway, Cytokine-cytokine receptor interaction |
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