FABP1 (1-127, His-Tag) Human Protein

SKU
AR09021PU-L
Recombinant human FABP1/L-FABP protein
  $1,135.00
3 Weeks*
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Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
MSFSGKYQLQ SQENFEAFMK AIGLPEELIQ KGKDIKGVSE IVQNGKHFKF TITAGSKVIQ NEFTVGEECE LETMTGEKVK TVVQLEGDNK LVTTFKNIKS VTELNGDIIT NTMTLGDIVF KRISKRI
Tag His-Tag
Predicted MW 16.3 kDa (147aa) confirmed by MALDI-TOF
Concentration 1mg/ml (determined by BCA assay)
Purity > 95% by SDS-PAGE
Presentation State Purified
Buffer Liquid in. 20mM Tris-HCl buffer (pH 8.0)
Endotoxin < 1 EU per 1ug of protein (determined by LAL method)
Preparation Liquid purified protein
Recommended Dilution SDS-PAGE
Protein Description Recombinant human FABP1, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Note NCBI Accession : NM_001443
Storage Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Reference Data
RefSeq NP_001434.1
Locus ID 2168
UniProt ID P07148
Cytogenetics 2p11.2
Synonyms Fatty acid binding protein 1, Fatty acid-binding protein, liver, FABPL, L-FABP, FABP1, Fatty acid binding protein 1, fatty acid binding protein 1 liver
Summary This gene encodes the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. This protein and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. provided by RefSeq, Mar 2011
Protein Categories Intracellular Proteins
Protein Pathways PPAR signaling pathway
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Documents
Resources

file-alt Citations

Endocannabinoid Interaction with Human FABP1: Impact of the T94A Variant
Martin, Huang, McIntosh et al
Biochemistry (2017) 56 (38), 5147-5159 DOI: 10.1021/acs.biochem.7b00647
AI Summary: OriGene contributed cDNA-encoding human FABP1, which was used to produce the recombinant wild-type (FABP1 T94T) and variant (FABP1 T94A) proteins studied in this paper.
Snippet: All solvents and reagents used were of the highest commercial grade available. Recombinant Human FABP1 T94T and FABP1 T94A Proteins cDNA-encoding human FABP1 was obtained from OriGene (Rockville, MD). The
Fatty Acid Binding Protein-1 (FABP1) and the Human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias
Schroeder, McIntosh, Martin et al
Lipids (2016) 51 (6), 655-76 DOI: 10.1007/s11745-016-4155-8
Cited by 60
AI Summary: In this paper, OriGene products, specifically the human FABP1 cDNA clone (OriGene, SC118395) and the human FABP1 T94A variant cDNA clone (OriGene, RC218395), were used to express and study the functional differences between wild-type and variant FABP1 proteins in relation to the endocannabinoid system and dyslipidemias.
FigureFigure
Human FABP1 T94A variant enhances cholesterol uptake
Huang, McIntosh, Landrock et al
Biochim. Biophys. Acta (2015) 1851 (7), 946-955 DOI: 10.1016/j.bbalip.2015.02.015
Cited by 25
AI Summary: OriGene contributed to this study by providing the human FABP1 cDNA used to generate recombinant wild-type and T94A variant proteins for in vitro cholesterol binding assays.
Snippet: Cruz Biotechnology, Dallas, TX). 2.2. Recombinant human FABP1 T94T and human T94A and rat FABP1 proteins. The cDNA encoding the human FABP1 was purchased from OriGene (Rockville, MD). Sequencing of this cDNA ... Cite SaveSaving
Human FABP1 T94A variant impacts fatty acid metabolism and PPAR-α activation in cultured human female hepatocytes
McIntosh, Huang, Storey et al
Am J Physiol Gastrointest Liver Physiol (2014) 307 (2), G164-76 DOI: 10.1152/ajpgi.00369.2013
Cited by 35
AI Summary: In this study, OriGene's human FABP1 cDNA clone (Cat# SC321071) and FABP1 shRNA plasmid (Cat# TL313254) were used to manipulate FABP1 expression in human hepatocytes, enabling the investigation of how the FABP1 T94A variant affects fatty acid metabolism and PPAR-α activation.
Showing 1-4 of 4 papers.
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