AKT1 / PKB (Substrate) Human Protein
|Description||AKT1 / PKB (Substrate) human protein, 0.5 mg|
|Predicted MW||817 Da|
|Concentration||1.0 mg/ml (by weight)|
|Purity||>98% pure by HPLC analysis.|
|Buffer||Presentation State: Purified
State: Liquid sterile filtered peptide
|Preparation||Liquid sterile filtered peptide|
|Applications||Western Blot: 1/500-1/2,000.|
|Protein Description||A specific substrate for Protein Kinase B alpha (PKB alpha, AKT; Km = 5 µM). This peptide is not phosphorylated by p70 S6 kinase or MAP kinase activated protein (MAPKAP) kinase-1.|
|Storage||Store the antibody (ibn aliquots) at -70°C or below prior to opening.
Avoid repeated freezing and thawing.
|Stability||Shelf life: 6 month from despatch.|
|Synonyms||AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA|
|Summary||The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]|
|Protein Families||Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase|
|Protein Pathways||Acute myeloid leukemia, Adipocytokine signaling pathway, Apoptosis, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, Glioma, Insulin signaling pathway, Jak-STAT signaling pathway, MAPK signaling pathway, Melanoma, mTOR signaling pathway, Neurotrophin signaling pathway, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer, Renal cell carcinoma, Small cell lung cancer, T cell receptor signaling pathway, Tight junction, Toll-like receptor signaling pathway, VEGF signaling pathway|
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