Interleukin-1 beta / IL-1B Chicken Protein

CAT#: AR05233PU-S

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Interleukin-1 beta / IL-1B chicken recombinant protein, 50 µg


Product Datasheet for 'AR05233PU-S'


USD 485.00


Availability*
5 Days

Size
    • 50 ug


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Specifications

Product Data
Description Interleukin-1 beta / IL-1B chicken recombinant protein, 50 µg
Species Chicken
Concentration 250 µg/ml
Purity >85% by Ni chelate Chromatography
Buffer State: Liquid purified protein
Buffer System: Phosphate buffered saline
Preparation Liquid purified protein
Applications In vitro Assay.
Functional Assays.
Protein Description His-tagged recombinant chicken interleukin-1 beta expressed in E.coli. This antigen induces corticosterone secretion in vivo(1) and is the immunogen used to produce chicken IL-1beta antibody product code SP2127A.
Storage Store the protein at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: 3 month from despatch.
Reference Data
RefSeq NP_000567
Locus ID 3553
Cytogenetics 2q14.1
Synonyms IL-1; IL1-BETA; IL1F2
Summary The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Alzheimer's disease, Apoptosis, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Graft-versus-host disease, Hematopoietic cell lineage, MAPK signaling pathway, NOD-like receptor signaling pathway, Prion diseases, Toll-like receptor signaling pathway, Type I diabetes mellitus

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