Interleukin-1 beta / IL-1B Chicken Protein
Interleukin-1 beta / IL-1B chicken recombinant protein, 50 µg
|Description||Interleukin-1 beta / IL-1B chicken recombinant protein, 50 µg|
|Purity||>85% by Ni chelate Chromatography|
|Buffer||State: Liquid purified protein
Buffer System: Phosphate buffered saline
|Preparation||Liquid purified protein|
|Applications||In vitro Assay.
|Protein Description||His-tagged recombinant chicken interleukin-1 beta expressed in E.coli. This antigen induces corticosterone secretion in vivo(1) and is the immunogen used to produce chicken IL-1beta antibody product code SP2127A.|
|Storage||Store the protein at -20°C.
Avoid repeated freezing and thawing.
|Stability||Shelf life: 3 month from despatch.|
|Synonyms||IL-1; IL1-BETA; IL1F2|
|Summary||The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]|
|Protein Families||Druggable Genome, Secreted Protein|
|Protein Pathways||Alzheimer's disease, Apoptosis, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Graft-versus-host disease, Hematopoietic cell lineage, MAPK signaling pathway, NOD-like receptor signaling pathway, Prion diseases, Toll-like receptor signaling pathway, Type I diabetes mellitus|