Interleukin-1 beta / IL-1B Chicken Protein
$685.00
5 Days*
Specifications
| Product Data | |
| Species | Chicken |
|---|---|
| Concentration | lot specific |
| Purity | >85% by Ni chelate Chromatography |
| Buffer | State: Liquid purified protein Buffer System: Phosphate buffered saline |
| Preparation | Liquid purified protein |
| Recommended Dilution | In vitro Assay. Functional Assays. |
| Protein Description | His-tagged recombinant chicken interleukin-1 beta expressed in E.coli. This antigen induces corticosterone secretion in vivo(1) and is the immunogen used to produce chicken IL-1beta antibody product code SP2127A. |
| Storage | Store the protein at -20°C. Avoid repeated freezing and thawing. |
| Stability | Shelf life: 3 month from despatch. |
| Shipping | Blue Ice |
| Reference Data | |
| RefSeq | NP_000567 |
| Locus ID | 3553 |
| UniProt ID | P01584 |
| Cytogenetics | 2q14.1 |
| Synonyms | IL-1 beta, IL1B, IL1 beta, IL1F2, Catabolin |
| Summary | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. provided by RefSeq, Jul 2020 |
| Protein Categories | Allergies and autoimmune diseases, Chemokines, Cytokines, Growth Factors, Intracellular Proteins, Secreated Proteins |
| Protein Families | In vitro Assay. Functional Assays. |
| Protein Pathways | Alzheimer's disease, Apoptosis, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Graft-versus-host disease, Hematopoietic cell lineage, MAPK signaling pathway, NOD-like receptor signaling pathway, Prion diseases, Toll-like receptor signaling pathway, Type I diabetes mellitus |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Citations
Andrographolide Against Lung Cancer-New Pharmacological Insights Based on High-Throughput Metabolomics Analysis Combined with Network Pharmacology
Luo, Jia, Zhang et al
Front Pharmacol (2021) 12, 596652 DOI: 10.3389/fphar.2021.596652
Luo, Jia, Zhang et al
Front Pharmacol (2021) 12, 596652 DOI: 10.3389/fphar.2021.596652
Cited by 12
AI Summary: In this study, OriGene products such as the GAPDH antibody (TA-08) and β-actin antibody (TA-09) were used as reference controls in Western blot experiments to assess protein expression changes in lung cancer models treated with andrographolide.
In vitro evaluation of a basic fibroblast growth factor-containing hydrogel toward vocal fold lamina propria scar treatment
Erndt-Marino, Jimenez-Vergara, Diaz-Rodriguez et al
J. Biomed. Mater. Res. Part B Appl. Biomater. (2017)
Erndt-Marino, Jimenez-Vergara, Diaz-Rodriguez et al
J. Biomed. Mater. Res. Part B Appl. Biomater. (2017)
AI Summary: OriGene products, including primers or reagents for iNOS, TNF, IL-12β, Arg-1, IL-10, Chi3l3, and GAPDH, were used to assess gene expression changes in macrophages and fibroblasts, enabling evaluation of the hydrogel's anti-fibrotic and anti-inflammatory effects.
Snippet: nitric oxide synthase (iNOS), tumor necrosis factor (TNF), subunit beta of interleukin 12 (IL-12β), arginase-1 (Arg-1), interleukin-10 (IL-10), chitinase-3 like protein 3 (Chi3l3), and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) were obtained from Origene or
Showing 1-2 of 2 papers.
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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