PKM2 Rabbit Protein
Specifications
| Product Data | |
| Species | Rabbit |
|---|---|
| Purity | 19% |
| Presentation State | Purified |
| Buffer | Presentation State: Purified State: Lyophilized purified protein |
| Bioactivity | Specific: 255.8 U/mg protein - 48.6 U/mg solid |
| Reconstitution Method | Reconstitute with sterile distilled water. For long term storage, addition of a preservative is recommended. |
| Preparation | Lyophilized purified protein |
| Recommended Dilution | ELISA. |
| Protein Description | Semi purified Pyruvate Kinase from rabbit muscle. Myokinase 0.005% GPD, CPK, ATPase, NADH, phospho-glycerate-mutase all 0.001%. The amount of enzyme that produces one micromole of pyruvate per minute at pH 7.6 from PEP in the presence of ADP at 30ºC. |
| Storage | Prior to reconstitution store at 2-8°C. Following reconstitution store the protein undiluted at -20°C. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Reference Data | |
| RefSeq | NP_001182573 |
| Locus ID | 100008676 |
| UniProt ID | P11974 |
| Synonyms | PK2, PK3, PKM, CTHBP, M2-PK, THBP1, OIP3, OIP-3, Pyruvate kinase 2/3, Pyruvate kinase M1/M2, Pyruvate kinase muscle |
| Summary | pyruvate kinase, muscle |
| Protein Families | ELISA. |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Citations
SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions
Bhardwaj, Das
Proc Natl Acad Sci U S A (2016) 113 (5), E538-47 DOI: 10.1073/pnas.1520045113
Bhardwaj, Das
Proc Natl Acad Sci U S A (2016) 113 (5), E538-47 DOI: 10.1073/pnas.1520045113
Cited by 151
AI Summary: In this paper, OriGene products—including the SIRT6 Myc-DDK-tagged overexpression plasmid (Cat# RC217445) and SIRT6 shRNA lentiviral particles (Cat# TL313503)—were used to modulate SIRT6 expression in cells, enabling the authors to investigate SIRT6’s role in deacetylating PKM2 and suppressing its oncogenic functions.
Showing 1-1 of 1 papers.
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