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Neuropeptide Y / NPY Human Protein

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SKU
AR05070PU-N
Neuropeptide Y / NPY human protein, 0.1 mg
Size:
100 ug
  $380.00
5 Days*
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Other products for "NPY or NM_000905"

Specifications
Specifications
Product Data
Species Human
Expression cDNA Clone or AA Sequence
Protein Sequence
Y-P-S-K-P-D-N-P-G-E-D-A-P-A-E-D-M-A-R-Y-Y-S-A-L-R-H-Y-I-N-L-I-T-R-Q-R-Y-NH2
Concentration lot specific
Purity >97% pure by HPLC
Presentation State Purified
Buffer Presentation State: Purified
State: Liquid purified synthetic peptide
Preservative: None
Stabilizer: None
Preparation Liquid purified synthetic peptide
Recommended Dilution ELISA.
Protein Description Synthetic Human Neuropeptide Tyrosine prepared by solid phase synthesis.
Storage Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Reference Data
RefSeq NP_000896
Locus ID 4852
UniProt ID P01303
Cytogenetics 7p15.3
Synonyms PYY4
Summary This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. provided by RefSeq, Oct 2014
Protein Categories Growth Factors, Secreated Proteins
Protein Families ELISA.
Protein Pathways Adipocytokine signaling pathway
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Documents
Resources

file-alt Citations

Sensory neurons in the human jugular ganglion
Atsumi, Yajima, Tachiya et al
Tissue Cell (2020) 64, 101344 DOI: 10.1016/j.tice.2020.101344
Cited by 22
AI Summary: In this study, OriGene products including anti-TRPV1 antibody (Cat# TA326021), anti-TRPV2 antibody (Cat# TA326023), anti-SPARCL1 antibody (Cat# TA327322), and anti-VGLUT2 antibody (Cat# TA336098) were used for immunohistochemical analysis to identify and characterize the distribution of specific proteins in human jugular ganglion sensory neurons.
Homozygous Truncating Variants in TBC1D23 Cause Pontocerebellar Hypoplasia and Alter Cortical Development
Ivanova, Mau-Them, Riazuddin et al
Am. J. Hum. Genet. (2017)
AI Summary: OriGene contributed three different 29-mer shRNA plasmids targeting mouse Tbc1d23, which were used to downregulate Tbc1d23 expression and study its role in cortical neuron positioning in this research.
Snippet: … Three different 29-mer shRNA sequences targeting mouse Tbc1d23 (GenBank: NM_026254) commercially designed and provided by Origene were cloned in the psiStrike vector under the control of a U6 promoter: shRNA-1, targeting the sequence ...;... … Three different 29-mer shRNA sequences targeting mouse Tbc1d23 (GenBank: NM_026254) commercially designed and provided by Origene were cloned in the psiStrike vector under the control of a U6 promoter: shRNA-1, targeting the sequence
Mechanisms by which the orexigen NPY regulates anorexigenic α-MSH and TRH
Cyr, Toorie, Steger et al
Am. J. Physiol. Endocrinol. Metab. (2013) 304 (6), E640-50 DOI: 10.1152/ajpendo.00448.2012
Cited by 42
AI Summary: OriGene products contributed to this study by providing NPY-Y1R and NPY-Y5R cDNA, which were used for transient transfection experiments to investigate the mechanisms by which NPY regulates α-MSH and TRH processing.
Snippet: Band density was analyzed using ImageJ (National Institutes of Health ... Depending on the experiment, cells were transiently transfected with a CMV plasmid containing PC2 cDNA (a gift from Dr. Nabil Seidah), Egr-1 cDNA (Addgene), or NPY-Y1R and NPY-Y5R cDNA (OriGene).
Showing 1-3 of 3 papers.
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