SNAP25B (1-206) Human Protein
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | E. coli |
| Expression cDNA Clone or AA Sequence | |
| Tag | His-tag |
| Predicted MW | 23.3 kDa (206aa) confirmed by MALDI-TOF |
| Concentration | 1mg/ml (determined by Bradford assay) |
| Purity | > 90% by SDS-PAGE |
| Presentation State | Purified |
| Buffer | Liquid in. 25mM Tris-HCl buffer (pH 7.5) containing 1mM DTT, 10% glycerol |
| Preparation | Liquid purified protein |
| Recommended Dilution | SDS-PAGE |
| Protein Description | Recombinant human SNAP25, fused to His tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
| Storage | Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Reference Data | |
| RefSeq | NP_570824.1 |
| Locus ID | 6616 |
| UniProt ID | P60880 |
| Cytogenetics | 20p12.2 |
| Synonyms | Synaptosomal-associated protein 25 isoform SNAP25B, FLJ23079, SNAP25, RIC-4, RIC4, SEC9, SNAP, SNAP-25, Synaptosomal-associated protein 25 isoform SNAP25B, Synaptosomal-associated protein 25 isoform SNAP25B SuP, Super protein, bA416N4.2, Bdr, dJ1068F16.2, HGNC:11132, MGC105414, MGC139754, Resistance to inhibitors of cholinesterase 4 homolog, RIC 4, SEC9, SNAP 25, SNAP-25B, SNP 25, SNP25, sp, Synaptosomal associated 25 kDa protein, Synaptosomal associated protein, Synaptosomal associated protein 25, Synaptosomal associated protein 25kDa. |
| Summary | Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. provided by RefSeq, Jul 2008 |
| Protein Categories | Growth Factors, Intracellular Proteins, Nervous system Diseases |
| Protein Families | Druggable Genome |
| Protein Pathways | SNARE interactions in vesicular transport |
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