Herbimycin A Protein

SKU AR03028PU-N

Herbimycin A protein, 1 mg

Product Data

• Predicted MW: 574.3
• Purity: >98% 98%
• Presentation State: Purified
• Buffer: Presentation State: Purified; State: Lyophilized solid; yellow
• Reconstitution Method: Soluble in DMSO and ethanol (1 mg/ml)
• Preparation: Lyophilized solid; yellow
• Recommended Dilution: Protocol: 1. Uehara Y.,and Fukazawa H. (1991) Methods Enzymol. 201: 370.; 2. Fukazawa H., et al. (1991) Biochem. Pharmacol. 42: 1661.; 3. Satoh T., et al.(1992) J.Biol.Chem. 267: 2537.; 4. Weiss R., and Nuccitelli R. (1992) J.Biol.Chem. 267:5608.
• Protein Description: Formula: C30H42N2O9
• Storage: Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.; Avoid repeated freezing and thawing.; Protect from light!
• Stability: Shelf life: One year from despatch.
• Shipping: Blue Ice

Reference Data

• Summary: Herbimycin A, a benzoquinoid ansamycin antibiotic, irreversibly and selectively inhibits tyrosine kinases by reacting with thiol groups (1,2). It is effective on Src, Yes, Fps, Ros, Abl and ErbB oncogene products (1-3) and inhibits thrombin-induced tyrosine phosphorylation of phospholipase C (4).
• Protein Families: and Fukazawa H. (1991) Methods Enzymol. 201: 370.<br />2. Fukazawa H., and Nuccitelli R. (1992) J.Biol.Chem. 267:5608., et al. (1991) Biochem. Pharmacol. 42: 1661.<br />3. Satoh T., et al.(1992) J.Biol.Chem. 267: 2537.<br />4. Weiss R., Protocol: 1. Uehara Y.