Geldanamycin Protein
Specifications
| Product Data | |
| Predicted MW | 1034.2 |
|---|---|
| Purity | >98% 98 % (TLC: 10 % Methanol.methylene chloride; Rf=0.31) |
| Conjugation | FITC |
| Buffer | State: Purple solid - FITC Presentation Label: FITC |
| Reconstitution Method | Soluble in DMSO (>10mg/ml) |
| Preparation | Purple solid - FITC |
| Protein Description | Formula: C55H63N5O13S |
| Storage | Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C. Avoid repeated freezing and thawing. Protect from light. |
| Stability | Shelf life: One year from despatch. |
| Shipping | Blue Ice |
| Reference Data | |
| Synonyms | Hsp90 inhibitor |
| Summary | Geldanamycin is a benzoquinoid ansamycin produced by Streptomyces hygroscopicus. It binds specifically to heat shock protein HSP90 and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases (1,2). It induces the inactivation, destabilization and eventual degradation of HIF-1α (3). This is specifically a novel geldanamycin fluorescent probe that may be used in a fluorescence polarization assay for Hsp90 inhibitors (4). May also be used for detection of cell surface Hsp90 (5). Other geldanamycin fluorophores (BODPY) have been reported and used in FP HTS assays (6,7) |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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