HSP90 Inhibitor Protein

SKU AR03024PU-N

HSP90 Inhibitor protein, 1 mg

Product Data

• Predicted MW: 558.7
• Purity: >98% pure (TLC: 5% Methanol/Methylene Chloride, Rf=0.26).
• Presentation State: Purified
• Buffer: Presentation State: Purified; State: Purple solid
• Reconstitution Method: Soluble in DMSO (>50 mg/ml) or Methanol (5 mg/ml).
• Preparation: Purple solid
• Protein Description: Red to dark red powder.; CAS No: 75747-14-7; Formula: C₃₁H₄₃N₃O₈
• Storage: Upon receipt, store at -20°C.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice

Reference Data

• Synonyms: 17-AAG
• Summary: Glendanamycin (GA), a benzoquinone ansamycin antibiotic, interferes with the action of Hsp90 leading to degradation of Hsp90 client proteins. GA itself however has undesirable properties such as poor aqueous solubility and liver toxicity; therefore, numerous analogs have been synthesized, such as 17-AAG(1). 17-AAG is an HSP-90 inhibitor that displays a 100-fold higher affinity for HSP-90 derived from tumor cells compared to HSP-90 from normal cells(2). 17- AAG inhibits Akt activation and expression in tumors and synergizes with a number of antitumor agents such as taxol(3), cisplatin(4) and UCN-01 (400 nM 17-AAG, U937 cells)(5).