Heat shock protein 70 / HSP70 (active) Human Protein
$820.00
2 Weeks*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | E. coli |
| Concentration | lot specific |
| Purity | >90% pure as determined by SDS-PAGE analysis. |
| Presentation State | Purified |
| Buffer | Presentation State: Purified State: Liquid affinity purified protein. Buffer System: 50 mM Tris/HCL, pH 7.5, 0.15 M NaCl, 10% Glycerol |
| Bioactivity | Biological: The protein has ATPase activity at the time of manufacture of 3.3 μM phosphate liberated/hr/μg protein in a 200 μl reaction at 37°C (pH7.5) in the presence of 20 µl of 1mM ATP using a Malachite Green assay. |
| Preparation | Liquid affinity purified protein. |
| Recommended Dilution | ATPase Assay. Western B Control. Binding Assays. ELISA reference standard. Lipid Interaction Assays. |
| Protein Description | Recombinant Human Hsp70 Protein with ATPase activity, his-tagged, cloned from a Human cDNA library |
| Storage | Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Reference Data | |
| RefSeq | NP_005336 |
| Locus ID | 3303 |
| UniProt ID | P0DMV8 |
| Cytogenetics | 6p21.33 |
| Synonyms | HSP70.1, HSP70-1/HSP70-2, HSPA1A, HSPA1B, HSPA1 |
| Summary | This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. provided by RefSeq, Jul 2008 |
| Protein Categories | Growth Factors, Intracellular Proteins |
| Protein Families | ATPase Assay. Western B Control. Binding Assays. ELISA reference standard. Lipid Interaction Assays. |
| Protein Pathways | Antigen processing and presentation, Endocytosis, MAPK signaling pathway, Prion diseases, Spliceosome |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Citations
Shallow water fish display low phenotypic plasticity to ocean warming and extreme weather events regardless of previous thermal history
Missionário, Almeida, Fernandes et al
Estuarine, Coastal and Shelf Science (2024) 305, 108849 DOI: 10.1016/j.ecss.2024.108849
Missionário, Almeida, Fernandes et al
Estuarine, Coastal and Shelf Science (2024) 305, 108849 DOI: 10.1016/j.ecss.2024.108849
Cited by 6
AI Summary: OriGene's HSP-70 standards (#AR03018PU-N) were used to construct calibration curves for biomarker quantification in the study.
Snippet: For both biomarkers quantification, calibration curves within a concentration range between 0 and 1 μg mL−1 were constructed (standards UbpBio, E−1100, USA for UBI and standards #AR03018PU-N, OriGene, USA for HSP-70)
Direct observation of chaperone-modulated talin mechanics with single-molecule resolution
Chakraborty, Chaudhuri, Banerjee et al
Commun Biol (2022) 5 (1), 307 DOI: 10.1038/s42003-022-03258-3
Chakraborty, Chaudhuri, Banerjee et al
Commun Biol (2022) 5 (1), 307 DOI: 10.1038/s42003-022-03258-3
Cited by 23
AI Summary: OriGene products Hsp70 (AR03018PU-N) and Hsp40 (AR09036PU-L) recombinant proteins were used in this study to investigate how these chaperones modulate the mechanical stability and folding dynamics of talin at the single-molecule level.
Snippet: fied by size exclusion chromatography using Superdex-200 increase 10/300 GL gel filtration column in presence of 150 mM NaCl (Supplementary Fig. 16)24. We purchased Hsp70 and Hsp40 chaperones from ORIGENE Technologies. AR03018PU-N (Hsp70, human recombinant protein) and AR09036PU-L (Hsp40, human recombinant protein). The purity of Hsp70 and Hsp40 is >90% and ≥95% as determined by SDS-PAGE anal
Showing 1-2 of 2 papers.
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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