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HSP90AA1 / HSP90 alpha Human Protein

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SKU
AR03017PU-S
HSP90AA1 / HSP90 alpha human recombinant protein, 50 µg
Size:
50 ug 2 x 100 ug
  $375.00
2 Weeks*
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Other products for "HSP90AA1 or NM_001017963"

Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Concentration lot specific
Purity >90% pure as determined by SDS-PAGE analysis (Purified by Multy-step Chromatography).
Presentation State Purified
Buffer Presentation State: Purified
State: Liquid protein
Buffer System: 50 mM Tris pH 7.5, 5 mM Bme, 0.3M NaCl, 10% Glycerol
Preparation Liquid protein
Recommended Dilution Western Blot Control, SDS-PAGE , ATPase Activity Assay, Surface Plasmon Resonance (SPR).
Specificity: ~90 kDa
Protein Description Recombinant Hsp90 alpha cloned from a Human cDNA library
Note Centrifuge vial before opening.
Storage Store at 2-8°C for one week or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Reference Data
RefSeq NP_001017963
Locus ID 3320
UniProt ID P07900
Cytogenetics 14q32.31
Synonyms HSP90A, HSPC1, HSPCA, Heat shock 86 kDa, HSP86, NY-REN-38, Heat shock protein HSP 90-alpha
Summary The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jan 2012
Protein Categories Intracellular Proteins
Protein Families ATPase Activity Assay, Surface Plasmon Resonance (SPR).
Specificity: ~90 kDa, SDS-PAGE , Western Blot Control
Protein Pathways Antigen processing and presentation, NOD-like receptor signaling pathway, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer
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Documents
Resources

file-alt Citations

Targeting the Hsp90 C-terminal domain to induce allosteric inhibition and selective client downregulation
Goode, Petrov, Vickman et al
Biochim Biophys Acta Gen Subj (2017) 1861 (8), 1992-2006 DOI: 10.1016/j.bbagen.2017.05.006
Cited by 38
AI Summary: OriGene products, specifically the anti-AR antibody (TA312204) and BRCA1 antibody (TA309281), were used in this study to detect and quantify the downregulation of androgen receptor (AR) and BRCA1 proteins following Hsp90 C-terminal domain inhibitor treatment, supporting the investigation of selective client protein degradation.
FigureFigure
Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson's disease patients
Saito, Akazawa-Ogawa, Matsumura et al
Sci Rep (2016) 6, 30793 DOI: 10.1038/srep30793
Cited by 41
AI Summary: OriGene products contributed to this paper by providing the anti-DJ-1 antibody (Cat# TA300166) used for detecting DJ-1 and its oxidized forms in erythrocyte lysates, enabling analysis of DJ-1 oxidation and interaction with the 20S proteasome in Parkinson’s disease research.
FigureFigureFigure
Experimental Anti-Inflammatory Drug Semapimod Inhibits TLR Signaling by Targeting the TLR Chaperone gp96
Wang, Grishin, Ford
J Immunol (2016) 196 (12), 5130-7 DOI: 10.4049/jimmunol.1502135
Cited by 30
AI Summary: In this study, OriGene products—including the anti-gp96 antibody (Cat# TA500602) and TLR4 cDNA clone (Cat# RC210926)—were used to detect gp96 protein and overexpress TLR4, respectively, thereby enabling key experiments that demonstrated Semapimod’s inhibition of TLR signaling via targeting the chaperone gp96.
FigureFigure
Identification of new FGF1 binding partners-Implications for its intracellular function
Bober, Olsnes, Kostas et al
IUBMB Life (2016) 68 (3), 242-51 DOI: 10.1002/iub.1480
Cited by 16
AI Summary: OriGene products contributed to this study by providing pEX-N-GST vectors encoding full-length nucleophosmin and a fragment of major vault protein, which were used to identify and confirm novel intracellular binding partners of FGF1.
Snippet: pEX-N-GST vectors encoding full-length nucleophosmin or fragment of major vault protein (113–474) [15] were obtained from Origene Technologies (MD, USA). Stable Transfection of HEK 293 Cells. Flp-In T-Rex 293 cells were seeded on polylysine-coated culture ... Cite SaveSaving
The rapid and direct determination of ATPase activity by ion exchange chromatography and the application to the activity of heat shock protein-90
Bartolini, Wainer, Bertucci et al
J Pharm Biomed Anal (2013) 73, 77-81 DOI: 10.1016/j.jpba.2012.03.021
Cited by 14
AI Summary: OriGene’s recombinant human Hsp90 protein (Cat# TP308508) was used as the enzyme source to assess ATPase activity with the newly developed ion exchange chromatography method described in the paper.
FigureFigure
Chaxamycins A-D, bioactive ansamycins from a hyper-arid desert Streptomyces sp
Rateb, Houssen, Arnold et al
J Nat Prod (2011) 74 (6), 1491-9 DOI: 10.1021/np200320u
Cited by 149
AI Summary: In this study, OriGene's HSP90 (NM_005348) human cDNA clone was used to facilitate experiments assessing the inhibitory effects of the newly discovered chaxamycins on Hsp90 ATPase activity.
Showing 1-6 of 7 papers.
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