CHRNA2 (NM_000742) Human Mass Spec Standard

SKU
PH320994
CHRNA2 MS Standard C13 and N15-labeled recombinant protein (NP_000733)
  $3,360.00
3 Weeks*
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Specifications
Specifications
Product Data
Tag C-Myc/DDK
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC220994
Predicted MW 59.75 kDa
Protein Sequence
Protein Sequence
>RC220994 representing NM_000742
Red=Cloning site Green=Tags(s)

MGPSCPVFLSFTKLSLWWLLLIPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETEDRLFKHLFRGY
NRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPADFGNITSLRVPSEMI
WIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAK
IDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLIS
CLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVL
NVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE
DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSVK
EDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Storage Store at -80°C. Avoid repeated freeze-thaw cycles.
Stability Stable for 3 months from receipt of products under proper storage and handling conditions.
Shipping Dry Ice
Reference Data
RefSeq NP_000733
RefSeq Size 2664
RefSeq ORF 1587
Locus ID 1135
UniProt ID Q15822
Cytogenetics 8p21.2
Summary Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. provided by RefSeq, Nov 2009
Protein Families Druggable Genome, Ion Channels: Cys-loop Receptors, Transmembrane
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Other "CHRNA2" proteins (3)
SKU Description Size Price
LC400246 Lyophilized CHRNA2 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY400246 Transient overexpression lysate of cholinergic receptor, nicotinic, alpha 2 (neuronal) (CHRNA2) (as WB positive control) 100 ug
$665.00
TP320994 Recombinant protein of human cholinergic receptor, nicotinic, alpha 2 (neuronal) (CHRNA2), 20 µg 20 ug
$867.00

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