PR3 (PRTN3) (NM_002777) Human Mass Spec Standard
Specifications
| Product Data | |
| Tag | C-Myc/DDK |
|---|---|
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | RC220949 |
| Predicted MW | 27.6 kDa |
| Protein Sequence | |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Labeling Method | Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
| Storage | Store at -80°C. Avoid repeated freeze-thaw cycles. |
| Stability | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_002768 |
| RefSeq Size | 1001 |
| RefSeq ORF | 768 |
| Synonyms | ACPA; AGP7; C-ANCA; CANCA; MBN; MBT; NP-4; NP4; P29; PR-3; PR3 |
| Locus ID | 5657 |
| UniProt ID | P24158 |
| Cytogenetics | 19p13.3 |
| Summary | Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279).UniProtKB/Swiss-Prot Function |
| Protein Families | Druggable Genome, Protease |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "PR3" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| LC400985 | Lyophilized PRTN3 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY400985 | Transient overexpression lysate of proteinase 3 (PRTN3) (as WB positive control) | 100 ug |
$436.00
|
|
| TP320949 | Recombinant protein of human proteinase 3 (PRTN3), 20 µg | 20 ug |
$867.00
|
|
Citations
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